GIInger predicts homologous recombination deficiency and patient response to PARPi treatment from shallow genomic profiles - CRCL-Analyse intégrée de la dynamique du cancer Access content directly
Journal Articles Cell Reports Medicine Year : 2023

GIInger predicts homologous recombination deficiency and patient response to PARPi treatment from shallow genomic profiles

Christian Pozzorini
  • Function : Author
Gregoire Andre
  • Function : Author
Tommaso Coletta
  • Function : Author
Adrien Buisson
  • Function : Author
Jonathan Bieler
  • Function : Author
Loïc Ferrer
  • Function : Author
Rieke Kempfer
  • Function : Author
Alexandre Harlé
Davide Vacirca
  • Function : Author
Massimo Barberis
  • Function : Author
Pauline Gilson
  • Function : Author
Cristin Roma
  • Function : Author
Alexandra Saitta
  • Function : Author
Ewan Smith
  • Function : Author
Floriane Consales Barras
  • Function : Author
Lucia Ripol
  • Function : Author
Martin Fritzsche
  • Function : Author
Ana Claudia Marques
  • Function : Author
Amjad Alkodsi
  • Function : Author
Ray Marin
  • Function : Author
Nicola Normanno
  • Function : Author
Christoph Grimm
  • Function : Author
Leonhard Müllauer
  • Function : Author
Philipp Harter
  • Function : Author
Sandro Pignata
  • Function : Author
Antonio Gonzalez-Martin
  • Function : Author
Ursula Denison
  • Function : Author
Keiichi Fujiwara
  • Function : Author
Ignace Vergote
  • Function : Author
Nicoletta Colombo
  • Function : Author
Adrian Willig
  • Function : Author
Eric Pujade-Lauraine
  • Function : Author
Pierre-Alexandre Just
  • Function : Author
Isabelle Ray-Coquard
  • Function : Author
Zhenyu Xu
  • Function : Author

Abstract

Highlights d Implementation hurdles restrict adoption of HRD testing, a PARPi response biomarker d GIInger leverages HRD-induced genome scarring from lowcoverage sequencing data d GIInger accurately stratifies ovarian cancer patients for PARPi treatment d GIInger is cost effective and seamlessly integrates into BRCA status workflows Authors

Domains

Cancer
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Dates and versions

hal-04400735 , version 1 (17-01-2024)

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Christian Pozzorini, Gregoire Andre, Tommaso Coletta, Adrien Buisson, Jonathan Bieler, et al.. GIInger predicts homologous recombination deficiency and patient response to PARPi treatment from shallow genomic profiles. Cell Reports Medicine, 2023, 4, ⟨10.1016/j.xcrm.2023.101344⟩. ⟨hal-04400735⟩
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