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Article dans une revue

A role for Dynlt3 in melanosome movement, distribution, acidity and transfer

Abstract : Skin pigmentation is dependent on cellular processes including melanosome biogenesis, transport, maturation and transfer to keratinocytes. However, how the cells finely control these processes in space and time to ensure proper pigmentation remains unclear. Here, we show that a component of the cytoplasmic dynein complex, Dynlt3, is required for efficient melanosome transport, acidity and transfer. In Mus musculus melanocytes with decreased levels of Dynlt3, pigmented melanosomes undergo a more directional motion, leading to their peripheral location in the cell. Stage IV melanosomes are more acidic, but still heavily pigmented, resulting in a less efficient melanosome transfer. Finally, the level of Dynlt3 is dependent on β-catenin activity, revealing a function of the Wnt/β-catenin signalling pathway during melanocyte and skin pigmentation, by coupling the transport, positioning and acidity of melanosomes required for their transfer.
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https://hal.sorbonne-universite.fr/hal-03203939
Contributeur : Hal Sorbonne Université Gestionnaire <>
Soumis le : mercredi 21 avril 2021 - 10:47:54
Dernière modification le : jeudi 2 septembre 2021 - 09:08:50
Archivage à long terme le : : jeudi 22 juillet 2021 - 18:27:58

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s42003-021-01917-5.pdf
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Zackie Aktary, Alejandro Conde-Perez, Florian Rambow, Mathilde Di Marco, François Amblard, et al.. A role for Dynlt3 in melanosome movement, distribution, acidity and transfer. Communications Biology, Nature Publishing Group, 2021, 4 (1), pp.423. ⟨10.1038/s42003-021-01917-5⟩. ⟨hal-03203939⟩

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