Evaluation of antibacterial textile covered by layer-by-layer coating and loaded with chlorhexidine for wound dressing application

Francois Aubert-Viard 1, 2 Alejandra Mogrovejo Valdivia 1 Nicolas Tabary 2 Mickael Maton 1 Feng Chai 1 Christel Neut 3 Bernard Martel 2 Nicolas Blanchemain 1, *
* Auteur correspondant
1 Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation
2 UMET - Unité Matériaux et Transformations - UMR 8207
3 LIRIC - Lille Inflammation Research International Center
Abstract : The aim of this work is to design a wound dressing able to release chlorhexidine (CHX) as antiseptic agent, ensuring long-lasting antibacterial efficacy during the healing. The textile nonwoven (polyethylene terephthalate) (PET) of the dressing was first modified by chitosan (CHT) crosslinked with genipin (Gpn). Parameters such as the concentration of reagents (Gpn and CHT) but also the crosslinking time and the working temperature were optimized to reach the maximal positive charges surface density. This support was then treated by the layer-by-layer (LbL) deposition of a multilayer system composed of methyl-beta-cyclodextrin polymer (PCD) (anionic) and CHT (cationic). After a thermal treatment to stabilize the LbL film, the textiles were loaded with CHX as antiseptic agent. The influence of the thermal treatment i) on the cytocompatibility, ii) on the degradation of the multilayer system, iii) on CHX sorption and release profiles and iv) on the antibacterial activity of the loaded textiles was studied.
Keywords : Cyclodextrin Chlorhexidine Antibacterial textile Chitosan Cytocompatibility Genipin Layer-by-layer
Type de document :
Article dans une revue
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https://hal.univ-lille.fr/hal-02114423
Contributeur : Lilloa Université de Lille <>
Soumis le : lundi 29 avril 2019 - 16:00:38
Dernière modification le : mercredi 5 juin 2019 - 14:58:02

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Francois Aubert-Viard, Alejandra Mogrovejo Valdivia, Nicolas Tabary, Mickael Maton, Feng Chai, et al.. Evaluation of antibacterial textile covered by layer-by-layer coating and loaded with chlorhexidine for wound dressing application. Materials Science and Engineering: C, Elsevier, 2019, Materials Science and Engineering: C, 100, pp.554-563. ⟨10.1016/j.msec.2019.03.044⟩. ⟨hal-02114423⟩

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