Growth, stool consistency and bone mineral content in healthy term infants fed sn-2-palmitate-enriched starter infant formula: A randomized, double-blind, multicentre clinical trial.
Résumé
BACKGROUND: Palmitate in breast milk is predominantly located in the triacylglycerol sn-2 position, while infant formulae contain palmitate predominantly in the sn-1 and sn-3 positions. During digestion, palmitate in the sn-1 and sn-3 positions is hydrolyzed to free palmitic acid that can subsequently complex with calcium to form insoluble soaps; this may partially explain why formula-fed infants have harder stools than breast-fed infants. METHODS: This large (n = 488) randomized, double-blind, multicentre trial investigated whether increasing the sn-2 palmitate content of infant formula improves stool consistency and bone mineral content (measured by dual-energy x-ray absorptiometry), without affecting growth or health. From approximately 1 week to 4 months of age, infants were exclusively fed one of three formulae: i) control formula (CF; 16% of total palmitate at sn-2; n = 162), (ii) experimental formula 1 (EF1; 43% of total palmitate at sn-2; n = 166) or (iii) experimental formula 2 (EF2; 51% of total palmitate at sn-2; n = 160). RESULTS: Intention-to-treat analysis showed softer stools in both EF groups (vs. CF) at ages 2 weeks and 1 and 2 months (p
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Sciences du Vivant [q-bio]
Origine : Publication financée par une institution
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Soumis le : jeudi 6 juin 2019-12:04:30
Dernière modification le : vendredi 19 avril 2024-14:04:05
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- HAL Id : hal-02149330 , version 1
- DOI : 10.1016/j.clnu.2018.05.015
- PUBMED : 29903473
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Laurent Beghin, Xavier Marchandise, Eric Lien, Myriam Bricout, Jean-Paul Bernet, et al.. Growth, stool consistency and bone mineral content in healthy term infants fed sn-2-palmitate-enriched starter infant formula: A randomized, double-blind, multicentre clinical trial.. Clinical nutrition (Edinburgh, Scotland), 2018, Clinical nutrition (Edinburgh, Scotland), ⟨10.1016/j.clnu.2018.05.015⟩. ⟨hal-02149330⟩
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