Evolutionary history of the 11p15 human mucin gene family.

Abstract : The four human mucin genes MUC6, MUC2, MUC5AC, and MUC5B are located at chromosome 11p15.5. It has been demonstrated that the three mucins MUC2, MUC5AC, and MUC5B contain several Cys-subdomains of 108 amino acid residues. In contrast, little information is available concerning MUC6. These Cys-subdomains contain 10 cysteine residues that have a highly conserved position. We present here a coherent probable evolutionary history of this human gene family after comparison of the nucleotide sequences of these Cys-subdomains. The three MUC loci MUC2, MUC5AC, and MUC5B may have evolved from a common ancestral gene by two successive duplications. Moreover, we can postulate that MUC5AC and MUC5B have evolved in a concerted manner, while MUC2 has evolved separately.
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Jean-Luc Desseyn, Marie Pierre Buisine, N Porchet, J P Aubert, P Degand, et al.. Evolutionary history of the 11p15 human mucin gene family.. Journal of Molecular Evolution, Springer Verlag, 1998, 46 (1), pp.102-106. ⟨10.1007/pl00006276⟩. ⟨hal-02177697⟩



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