Structure and function of the polymeric mucins in airways mucus, Annu. Rev. Physiol, vol.70, pp.459-486, 2008. ,
Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection, Gastroenterology, vol.138, pp.1763-1771, 2010. ,
Colorectal cancer in mice genetically deficient in the mucin Muc2, Science, vol.295, pp.1726-1729, 2002. ,
New concepts of the pathogenesis of cystic fibrosis lung disease, Eur. Respir. J, vol.23, pp.146-158, 2004. ,
Airway mucus hypersecretion in asthma: an undervalued pathology?, Curr. Opin. Pharmacol, vol.4, pp.241-250, 2004. ,
, Nature, vol.505, pp.412-416, 2014.
Mucus supramolecular topology: an elusive riddle, Proc. Natl. Acad. Sci. U.S.A, vol.109, 2012. ,
Genomic organization of the human mucin gene MUC5B: cDNA and genomic sequences upstream of the large central exon, J. Biol. Chem, vol.273, pp.30157-30164, 1998. ,
URL : https://hal.archives-ouvertes.fr/hal-02177055
Molecular cloning of human intestinal mucin (MUC2) cDNA: identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor, J. Biol. Chem, vol.269, pp.2440-2446, 1994. ,
Assembly of Weibel-Palade body-like tubules from N-terminal domains of von Willebrand factor, Proc. Natl. Acad. Sci. U.S.A, vol.105, pp.482-487, 2008. ,
Willebrand factor assembly and secretion, J. Thromb. Haemost. 7, Suppl, vol.1, pp.24-27, 2009. ,
Willebrand factor proteolytic processing and multimerization precede the formation of WeibelPalade bodies, Blood, vol.83, pp.3536-3544, 1994. ,
Human MUC5AC mucin dimerizes in the rough endoplasmic reticulum, similarly to the MUC2 mucin, Biochem. J, vol.335, pp.381-387, 1998. ,
Porcine submaxillary mucin forms disulfide-linked multimers through its aminoterminal D-domains, J. Biol. Chem, vol.273, pp.14442-14449, 1998. ,
Porcine submaxillary mucin forms disulfide-bonded dimers between its carboxyl-terminal domains, J. Biol. Chem, vol.271, pp.9845-9850, 1996. ,
Identification of molecular intermediates in the assembly pathway of the MUC5AC mucin, J. Biol. Chem, vol.279, pp.15698-15705, 2004. ,
Molecular mechanism of product storage and release in mucin secretion. II. The role of extracellular Ca ??, Biorheology, vol.24, pp.625-633, 1987. ,
Molecular mechanism of mucin secretion: I. The role of intragranular charge shielding, J. Dent. Res, vol.66, pp.506-508, 1987. ,
Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus, J. Biol. Chem, vol.278, pp.28703-28710, 2003. ,
Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin, Proc. Natl. Acad. Sci. U.S.A, vol.109, pp.5645-5650, 2012. ,
Unpacking a gel-forming mucin: a view of MUC5B organization after granular release, Am. J. Physiol. Lung Cell. Mol. Physiol, vol.298, pp.15-22, 2010. ,
Concentrated solutions of salivary MUC5B mucin do not replicate the gel-forming properties of saliva, Biochem. J, vol.362, pp.289-296, 2002. ,
Molecular basis of elastic fiber formation: critical interactions and a tropoelastin-fibrillin-1 cross-link, J. Biol. Chem, vol.279, pp.23748-23758, 2004. ,
Characterization of mucins from cultured normal human tracheobronchial epithelial cells, Am. J. Physiol. Lung Cell. Mol. Physiol, vol.278, pp.1118-1128, 2000. ,
Identification of two glycoforms of the MUC5B mucin in human respiratory mucus: evidence for a cysteine-rich sequence repeated within the molecule, J. Biol. Chem, vol.272, pp.9561-9566, 1997. ,
EMAN2: an extensible image processing suite for electron microscopy, J. Struct. Biol, vol.157, pp.38-46, 2007. ,
Structure and mechanism of the PilF DNA transformation ATPase from Thermus thermophilus, Biochem. J, vol.450, pp.417-425, 2013. ,
HYDROMIC: prediction of hydrodynamic properties of rigid macromolecular structures obtained from electron microscopy images, Eur. Biophys. J, vol.30, pp.457-462, 2001. ,
Automated acquisition and analysis of small angle x-ray scattering data, Nucl. Instrum. Methods Phys. Res. A, vol.689, pp.52-59, 2012. ,
Uniqueness of ab initio shape determination in small-angle scattering, J. Appl. Crystallogr, vol.36, pp.860-864, 2003. ,
Calculation of hydrodynamic properties of globular proteins from their atomic-level structure, Biophys. J, vol.78, pp.719-730, 2000. ,
Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and Lamm equation modeling, Biophys. J, vol.78, pp.1606-1619, 2000. ,
Mucous granule exocytosis and CFTR expression in gallbladder epithelium, Glycobiology, vol.10, pp.149-157, 2000. ,
Calcium binding to biliary mucins is dependent on sodium ion concentration: relevance to cystic fibrosis, Biochem. Biophys. Res. Commun, vol.314, pp.330-334, 2004. ,
Determination of the regularization parameter in indirect-transform methods using perceptual criteria, J. Appl. Crystallogr, vol.25, pp.495-503, 1992. ,
Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing, Biophys. J, vol.76, pp.2879-2886, 1999. ,
Glycopolymer charge density determines conformation in human ocular mucin gene products: an atomic force microscope study, J. Struct. Biol, vol.145, pp.246-253, 2004. ,
The N terminus of the MUC2 mucin forms trimers that are held together within a trypsinresistant core fragment, J. Biol. Chem, vol.277, pp.47248-47256, 2002. ,
Analysis of respiratory mucus glycoproteins in asthma: a detailed study from a patient who died in status asthmaticus, Am. J. Respir. Cell Mol. Biol, vol.13, pp.748-756, 1995. ,
Mucin granule intraluminal organization in living mucous/ goblet cells: roles of protein post-translational modifications and secretion, J. Biol. Chem, vol.281, pp.4844-4855, 2006. ,
A new role for bicarbonate in mucus formation, Am. J. Physiol. Lung Cell. Mol. Physiol, vol.299, pp.542-549, 2010. ,
Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium, Proc. Natl. Acad. Sci. U.S.A, vol.100, pp.16083-16088, 2003. ,
Effects of calcium on intestinal mucin: implications for cystic fibrosis, Pediatr. Res, vol.10, pp.609-613, 1976. ,
Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype, J. Exp. Med, vol.209, pp.1263-1272, 2012. ,
Birth of mucus, Am. J. Physiol. Lung Cell. Mol. Physiol, vol.298, pp.13-14, 2010. ,
,
, GEL-FORMING MUCIN Assembly of the Respiratory Mucin MUC5B: A NEW MODEL FOR A, vol.289, pp.16409-16420, 2014.
URL : https://hal.archives-ouvertes.fr/hal-02178621
, J. Biol. Chem
, Access the most updated version of this article at doi