Gel-forming mucin interactome drives mucus viscoelasticity, Adv. Colloid Interface Sci, vol.252, pp.69-82, 2018. ,
Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse, Genomics, vol.81, pp.36-39, 2003. ,
URL : https://hal.archives-ouvertes.fr/hal-02177647
Architecture of the large membrane-bound mucins, Gene, vol.410, pp.215-237, 2008. ,
A mouse model of keratoconjunctivitis sicca, Invest. Ophthalmol. Vis. Sci, vol.43, pp.632-638, 2002. ,
Smallmolecule CFTR activators increase tear secretion and prevent experimental dry eye disease, FASEB J, vol.30, pp.1789-1797, 2016. ,
Mucin deficiency causes functional and structural changes of the ocular surface, PLoS One, vol.7, 2012. ,
Distribution of mucins at the ocular surface, Exp. Eye Res, vol.78, pp.379-388, 2004. ,
Human conjunctival goblet cells express the membrane associated mucin MUC16: Localization to mucin granules, Exp. Eye Res, vol.145, pp.230-234, 2016. ,
Visualization of conjunctival goblet cell actin cytoskeleton and mucin content in tissue whole mounts, Exp. Eye Res, vol.65, pp.407-415, 1997. ,
Mouse conjunctival forniceal gene expression during postnatal development and its regulation by krüppel-like factor 4, Investig. Ophthalmol. Vis. Sci, vol.52, pp.4951-4962, 2011. ,
Expression patterns of sialylated epitope recognized by KL-6 monoclonal antibody in ocular surface epithelium of normals and dry eye patients, Investig. Ophthalmol. Vis. Sci, vol.45, pp.2212-2217, 2004. ,
C/EBPalpha and C/EBPbeta are required for Sebocyte differentiation and stratified squamous differentiation in adult mouse skin, PLoS One, vol.5, 2010. ,
FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate, Development, vol.136, pp.1741-1750, 2009. ,
Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye, PLoS One, vol.9, 2014. ,
Compensatory increases in tear volume and mucin levels associated with meibomian gland dysfunction caused by stearoyl-CoA desaturase-1 deficiency, Sci. Rep, vol.8, 2018. ,
Hyperlipidemia and cutaneous abnormalities in transgenic mice overexpressing human apolipoprotein C1, J. Clin. Invest, vol.101, pp.145-152, 1998. ,
Bacterial conjunctivitis in Muc1 null mice, Invest. Ophthalmol. Vis. Sci, vol.40, pp.1328-1335, 1999. ,
Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells, Dev. Biol, vol.356, pp.5-18, 2011. ,
RGN-259 (thymosin ?4) improves clinically important dry eye efficacies in comparison with prescription drugs in a dry eye model, Sci. Rep, vol.8, p.10500, 2018. ,
Topical application of apricot kernel extract improves dry eye symptoms in a unilateral exorbital lacrimal gland excision mouse, Nutrients, vol.8, 2016. ,
Transduced PEP-1-FK506BP ameliorates corneal injury in Botulinum toxin A-induced dry eye mouse model, BMB Rep, vol.46, pp.124-129, 2013. ,
The effects of 3% diquafosol sodium application on the tear functions and ocular surface of the Cu,Zn-superoxide dismutase-1 (Sod1)-knockout mice, Mol. Vis, vol.20, pp.929-938, 2014. ,
Age-related dysfunction of the lacrimal gland and oxidative stress: evidence from the Cu,Zn-superoxide dismutase-1 (Sod1) knockout mice, Am. J. Pathol, vol.180, pp.1879-1896, 2012. ,
Mucin gene expression is not regulated by estrogen and/or progesterone in the ocular surface epithelia of mice, Exp. Eye Res, vol.77, pp.59-68, 2003. ,
Current concepts: mouse models of Sjögren's syndrome, J. Biomed. Biotechnol, pp.1-14, 2011. ,
A new ophthalmic pharmaceutical formulation, topical sulglycotide, enhances the ocular mucin secretion in desiccation stressmediated dry eye disease, Investig. Ophthalmol. Vis. Sci, vol.60, pp.1076-1087, 2019. ,
Topical TSG-6 administration protects the ocular surface in two mouse models of inflammation-related dry eye, Invest. Ophthalmol. Vis. Sci, vol.56, pp.5175-5181, 2015. ,
Mesenchymal stem/stromal cells protect the ocular surface by suppressing inflammation in an experimental dry eye, Mol. Ther, vol.23, pp.139-146, 2015. ,
Requirement of fatty acid transport protein 4 for development, maturation, and function of sebaceous glands in a mouse model of ichthyosis prematurity syndrome, J. Biol. Chem, vol.288, pp.3964-3976, 2013. ,
,
A mouse dry eye model induced by topical administration of benzalkonium chloride, Mol. Vis, vol.17, pp.257-264, 2011. ,
Two patients with dry eye disease followed up using an expression assay of ocular surface mucin, Case Rep. Ophthalmol, vol.7, pp.208-215, 2016. ,
Dry eye disease in French elderly subjects: the Alienor Study, Acta Ophthalmol, vol.92, pp.429-436, 2014. ,
The cellular mechanisms of dry eye: from pathogenesis to treatment, J. Cell. Physiol, vol.228, pp.2253-2256, 2013. ,
Spdef null mice lack conjunctival goblet cells and provide a model of dry eye, Am. J. Pathol, vol.183, pp.35-48, 2013. ,
The ocular surface phenotype of Muc5ac and Muc5b null mice, Invest. Ophthalmol. Vis. Sci, vol.55, pp.291-300, 2014. ,
Suppression of Toll-like receptor-mediated innate immune responses at the ocular surface by the membrane-associated mucins MUC1 and MUC16, Mucosal Immunol, vol.8, pp.1000-1008, 2015. ,
Morphological and histochemical studies of goblet cells in developing human conjunctiva, Jpn. J. Ophthalmol, vol.36, pp.169-174, 1992. ,
Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid, J. Nutr, vol.131, pp.2260-2268, 2001. ,
Comparison of ocular surface mucin expression after topical ophthalmic drug administration in dry eye-induced mouse model, J. Ocul. Pharmacol. Ther, vol.34, pp.612-620, 2018. ,
Impression cytology on conjunctiva and cornea in dry eye patients establishes a correlation between squamous metaplasia and dry eye clinical severity, Eur. J. Ophthalmol, vol.13, pp.115-127, 2003. ,
TRAF6-deficient mice display hypohidrotic ectodermal dysplasia, Proc. Natl. Acad. Sci. U. S. A, vol.99, pp.8766-8771, 2002. ,
The effects of 2% rebamipide ophthalmic solution on the tear functions and ocular surface of the superoxide dismutase-1 (sod1) knockout mice, Investig. Ophthalmol. Vis. Sci, vol.54, pp.7793-7802, 2013. ,
,
K14 + compound niches are present on the mouse cornea early after birth and expand after debridement wounds, Dev. Dyn, vol.245, pp.132-143, 2016. ,
Isolation and characterization of MUC15, a novel cell membrane-associated mucin, Eur. J. Biochem, vol.269, pp.2755-2763, 2002. ,
Transcriptome analysis of aging mouse meibomian glands, Mol. Vis, vol.22, pp.518-527, 2016. ,
Human lacrimal gland mucins, Cell Tissue Res, vol.316, pp.167-177, 2004. ,
Detection of sialomucin complex (MUC4) in human ocular surface epithelium and tear fluid, Investig. Ophthalmol. Vis. Sci, vol.41, pp.1316-1326, 2000. ,
Morpho-regulation of ectodermal organs: integument pathology and phenotypic variations in K14-Noggin engineered mice through modulation of bone morphogenic protein pathway, Am. J. Pathol, vol.164, issue.10, pp.63197-63202, 2004. ,
Preclinical mouse model to monitor live Muc5b-producing conjunctival goblet cell density under pharmacological treatments 12, 2017. ,
In vivo imaging of the Muc5b gel-forming mucin, Sci. Rep, vol.7, 2017. ,
Fibroblast growth factor receptor 2 (FGFR2) is required for meibomian gland homeostasis in the adult mouse, Investig. Ophthalmol. Vis. Sci, vol.58, pp.2638-2646, 2017. ,
Cell surface O-glycans limit Staphylococcus aureus adherence to corneal epithelial cells, Infect. Immun, vol.76, pp.5215-5220, 2008. ,
Recovery of radiation-induced dry eye and corneal damage by pretreatment with adenoviral vectormediated transfer of erythropoietin to the salivary glands in mice, Hum. Gene Ther, vol.24, pp.417-423, 2013. ,
A new Mel-CAM (CD146)-specific monoclonal antibody, MN-4, on paraffin-embedded tissue, Mod. Pathol, vol.11, pp.1098-1106, 1998. ,
Symptoms, visual function, and mucin expression of eyes with tear film instability, Cornea, vol.32, pp.1211-1218, 2013. ,
Variations of dry eye disease prevalence by age, sex and geographic characteristics in China: a systematic review and meta-analysis, J. Glob. Health, vol.8, p.20503, 2018. ,
Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca, Invest. Ophthalmol. Vis. Sci, vol.44, pp.4223-4229, 2003. ,
Assay of mucins in human tear fluid, Exp. Eye Res, vol.84, pp.939-950, 2007. ,
, TFOS DEWS II Epidemiology Report. Ocul. Surf, vol.15, pp.334-365, 2017.
Altered mucin and glycoprotein expression in dry eye disease, Optom. Vis. Sci, vol.92, pp.931-938, 2015. ,
Extraorbital lacrimal gland excision: a reproducible model of severe aqueous tear-deficient dry eye disease, Cornea, vol.33, pp.1336-1341, 2014. ,
Botulinum toxin B-induced mouse model of keratoconjunctivitis sicca, Invest. Ophthalmol. Vis. Sci, vol.47, pp.133-139, 2006. ,
Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells, Mol. Cell. Biol, vol.27, pp.182-194, 2007. ,
High incidence of autoimmune dacryoadenitis in male non-obese diabetic (NOD) mice depending on sex steroid, Clin. Exp. Immunol, vol.109, pp.555-561, 1997. ,
Characterization of the mucocutaneous junction of the human eyelid margin and meibomian glands with different biomarkers, Ann. Anat, vol.194, pp.436-445, 2012. ,
Structure and function of the polymeric mucins in airways mucus, Annu. Rev. Physiol, vol.70, pp.459-486, 2008. ,
,
Special Senses, Comparative Anatomy and Histology, pp.395-418, 2012. ,
Barx2 and Fgf10 regulate ocular glands branching morphogenesis by controlling extracellular matrix remodeling, Development, vol.138, pp.3307-3317, 2011. ,
Prevalence of dry eye disease and its risk factors in visual display terminal users: The Osaka study, Am. J. Ophthalmol, vol.156, pp.759-766, 2013. ,
A new mouse model of dry eye disease: oxidative stress affects functional decline in the lacrimal gland, Cornea, vol.31, issue.1, pp.63-67, 2012. ,
Alteration of tear mucin 5AC in office workers using visual display terminals: The Osaka study, JAMA Ophthalmol, vol.132, pp.985-992, 2014. ,
Tissue-based map of the human proteome, vol.347, p.1260419, 2015. ,
Pathological analysis of ocular lesions in a murine model of Sjögren's syndrome, Int. J. Mol. Sci, vol.18, 1209. ,
Topical administration of interleukin-1 receptor antagonist as a therapy for aqueous-deficient dry eye in autoimmune disease, Mol. Vis, vol.19, pp.1957-1965, 2013. ,
Alteration of ocular surface mucins in MUC5AC-DTA transgenic mice, Mol. Vis, vol.15, pp.108-119, 2009. ,
Meibomian gland absence related dry eye in ectodysplasin a mutant mice, Am. J. Pathol, vol.186, pp.32-42, 2016. ,
, TFOS DEWS II Tear Film Report. Ocul. Surf, vol.15, pp.366-403, 2017.
Expression analysis of the transmembrane mucin MUC20 in human corneal and conjunctival epithelia, Investig. Ophthalmol. Vis. Sci, vol.55, pp.6132-6138, 2014. ,
Loss of NHE8 expression impairs ocular surface function in mice, Am. J. Physiol. Cell Physiol, vol.308, pp.79-87, 2015. ,
Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia, J. Biol. Chem, vol.275, pp.21324-21330, 2000. ,
MUC19 expression in human ocular surface and lacrimal gland and its alteration in Sjögren syndrome patients, Exp. Eye Res, vol.86, pp.403-411, 2008. ,
,
Interferon-? exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways, Investig. Ophthalmol. Vis. Sci, vol.52, pp.6279-6285, 2011. ,
Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye, Exp. Eye Res, vol.118, pp.117-124, 2014. ,
Therapeutic effects of topical doxycycline in a benzalkonium chloride-induced mouse dry eye model, Investig. Ophthalmol. Vis. Sci, vol.55, pp.2963-2974, 2014. ,
Efficacy of trabodenoson in a mouse keratoconjunctivitis sicca (KCS) model for dry-eye syndrome, Investig. Ophthalmol. Vis. Sci, vol.59, pp.3088-3093, 2018. ,
A single injection of interleukin-1 induces reversible aqueous-tear deficiency, lacrimal gland inflammation, and acinar and ductal cell proliferation, Exp. Eye Res, vol.84, pp.894-904, 2007. ,