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Guided tissue regeneration membranes with controlled delivery properties of chlorhexidine by their functionalization with cyclodextrins

Abstract : In parodontology, guided tissue regeneration (GTR) is a new technique to cure periodontal lesions. Where the association of the GTR with an antimicrobial agent does not yield optimal results, we used the properties of cyclodextrins (CDs) to improve the membrane used in RTG to control the release and to increase the quantity of antimicrobial agent stocked on the membrane. We successed in fixing 14%-wt of cyclodextrin polymer on polyvinylidene difluoride (PVDF) membranes thank to citric acid (CTR) as crosslinking agent. We studied the complexation of chlorhexidine diacetate (CHX), the antiseptic agent used in this study, with CDs in UV-spectrophotometry and ROESY NMR. We observed complexation of CHX by b, c, hydroxypropylated (HP) bCD. We studied the biological properties of the cyclodextrin polymer onto (PVDF) membranes and observed that the CDs-polymer is not harmful for the cells. Moreover it stimulates their growth with native CD. A kinetic of release of the CHX was performed. Raw membranes released all CHX stocked in few hours, whereas grafted membranes released more than tenfold this quantity during 60–80 days.
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https://hal.univ-lille.fr/hal-02298623
Contributeur : Lilloa Université de Lille <>
Soumis le : vendredi 27 septembre 2019 - 08:40:42
Dernière modification le : mardi 17 mars 2020 - 03:17:00

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  • HAL Id : hal-02298623, version 1

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Stéphane Leprêtre, François Boschin, Nicolas Tabary, Marc Bria, Bernard Martel, et al.. Guided tissue regeneration membranes with controlled delivery properties of chlorhexidine by their functionalization with cyclodextrins. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2007, Journal of Inclusion Phenomena and Macrocyclic Chemistry, 57, pp.297-302. ⟨hal-02298623⟩

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