Functionalization of PVDF membranes with carbohydrate derivates for the controlled delivery of chlorhexidin

Nicolas Tabary 1 Stéphane Leprêtre François Boschin Nicolas Blanchemain 2 Christel Neut Elisabeth Delcourt Debruyne 2 Bernard Martel 1 Michel Morcellet Hartmut Frederic Hildebrand
1 UMET - Unité Matériaux et Transformations - UMR 8207
2 Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation
Abstract : Maltodextrin (MX) was fixed onto PVDF membranes in order to create a drug delivery Guided Tissue Regeneration (GTR) device with controlled drug delivery properties. PVDF microporous membranes were treated by a mixture of MX and citric acid, resulting to an 18 wt% increase of the supports. MX grafted membrane could capture 103 mg/g chlorhexidin digluconate(DigCHX) instead of 1 mg/g for a Virgin membrane. A neutralization step was performed before the biological tests. Viability tests confirmed the non-toxicity of the MX polymer coating after neutralisation. In vitro release test in human plasma, and microbiological tests showed that membranes grafted with MX were more performing compared to virgin and b-CD grafted membranes. The antimicrobial activity was effective during more than 72 h.
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https://hal.univ-lille.fr/hal-02313698
Contributeur : Lilloa Université de Lille <>
Soumis le : vendredi 11 octobre 2019 - 14:42:56
Dernière modification le : mardi 17 décembre 2019 - 14:23:25

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Nicolas Tabary, Stéphane Leprêtre, François Boschin, Nicolas Blanchemain, Christel Neut, et al.. Functionalization of PVDF membranes with carbohydrate derivates for the controlled delivery of chlorhexidin. Biomolecular Engineering, 2007, Biomolecular Engineering, 24, pp.472-476. ⟨10.1016/j.bioeng.2007.07.007⟩. ⟨hal-02313698⟩

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