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Brain Magnetic Susceptibility Changes in Patients with Natalizumab-Associated Progressive Multifocal Leukoencephalopathy
Abstract : We investigated the brain magnetic susceptibility changes induced by natalizumab-associated progressive multifocal leukoencephalopathy. We retrospectively included 12 patients with natalizumab-progressive multifocal leukoencephalopathy, 5 with progressive multifocal leukoencephalopathy from other causes, and 55 patients with MS without progressive multifocal leukoencephalopathy for comparison. MR imaging examinations included T2* or SWI sequences in patients with progressive multifocal leukoencephalopathy (86 examinations) and SWI in all patients with MS without progressive multifocal leukoencephalopathy. Signal abnormalities on T2* and SWI were defined as low signal intensity within the cortex and/or U-fibers and the basal ganglia. We observed T2* or SWI signal abnormalities at the chronic stage in all patients with progressive multifocal leukoencephalopathy, whereas no area of low SWI signal intensity was detected in patients without progressive multifocal leukoencephalopathy. Among the 8 patients with asymptomatic natalizumab-progressive multifocal leukoencephalopathy, susceptibility changes were observed in 6 (75%). The basal ganglia adjacent to progressive multifocal leukoencephalopathy lesions systematically appeared hypointense by using T2* and/or SWI. Brain magnetic susceptibility changes may be explained by the increased iron deposition and constitute a useful tool for the diagnosis of progressive multifocal leukoencephalopathy.
Mots-clés :
Mesh:Aged
Mesh:Antibodies
Mesh:Monoclonal
Mesh:Humanized/adverse effects
Mesh:Brain/pathology
Mesh:Female
Mesh:Humans
Mesh:Immunologic Factors/adverse effects*
Mesh:Leukoencephalopathy
Mesh:Progressive Multifocal/chemically induced*
Mesh:Progressive Multifocal/diagnosis*
Mesh:Magnetic Resonance Imaging/adverse effects
Mesh:Male
Mesh:Natalizumab/adverse effects*
Mesh:Retrospective Studies
Mesh:Middle Aged
https://hal.univ-lille.fr/hal-02368327
Contributeur : Lilloa Université de Lille <>
Soumis le : lundi 18 novembre 2019 - 14:51:15
Dernière modification le : vendredi 16 juillet 2021 - 08:57:19
Contributeur : Lilloa Université de Lille <>
Soumis le : lundi 18 novembre 2019 - 14:51:15
Dernière modification le : vendredi 16 juillet 2021 - 08:57:19
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