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, Group: P <0.001
, Group: NS
, Group: NS
, Group: NS
, Exercise: P <0.05
, Group: P < 0.05
, Exercise: P < 0, Group: P < 0.05, vol.001
, Values are means ± SD. Main effects from mixed models: Exercise, Exercise effect
, Post hoc analyses for group effect: significantly different from controls at * P < 0.05; post hoc analyses for time effect: significantly different from rest at ? P
, HR: heart rate; RER: respiratory exchange ratio; DLCO and DLNO: lung diffusion capacity for carbon monoxide and for nitric oxide
, ?, corrected by individual hemoglobin concentrations
, Dm: membrane transfer capacity; Vc: capillary lung volume, vol.2, p.3
,
, Plasma (fluorinated) glucose was measured with hexokinase enzymatic assay on modular automatic analyzer; serum free insulin with noncompetitive radioimmunoassay (Cisbio), plasma (heparin, metabisulfite) catecholamines with HPLC, serum free fatty acids and glycerol with colorimetric assays (RANDOX reagents), arterialized (vasodilatory pomade applied 5 min before) erythrocyte 2,3-DPG using spectrophotometry (Sigma-Aldrich), and arterialized pH, K + , PaCO2 by potentiometry, SaO2 and Hb by spectrophotometry, p.2
, Main effects from mixed models: Exercise, Exercise effect
, Post hoc analyses for group effect: significantly different from controls at *** P<0.001. Post hoc analyses for time effect: significantly different from rest at ? ? P<0.01, and ? ? ? P<0.001. Change in ?THb (A)
, The 40 mm-interspersed emitter-detector pair was placed on the belly of the right vastus lateralis muscle. NIRS outcomes changes are displayed according to exercise intensities expressed as relative values (% V?O %&'( ). Mixed models revealed almost identical results when studying NIRS according to absolute exercise intensities (i.e., expressed as absolute work rates in Watts