Genetic underpinnings in Alzheimer's disease - a review

Ahmed A. Moustafa Mubashir Hassan Doaa H. Hewedi Iman Hewedi Julia K. Garami Hany Al Ashwal Nazar Zaki Sung-Yum Seo Vassilis Cutsuridis Sergio L. Angulo Joman Y. Natesh Mohammad M. Herzallah Dorota Frydecka Błażej Misiak Mohamed Salama Wael Mohamed Mohamad El Haj 1 Michael Hornberger
1 SCALab - Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Abstract : In this review, we discuss the genetic etiologies of Alzheimer's disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the clumps of AD-m ediated genes according to their single nucleotide polymorphism mutations. Rigorous data mining approaches justified the significant role of genes in AD prevalence. Pedigree analysis and twin studies suggest that genetic components are part of the etiology, rather than only being risk factors for AD. The first autosomal dominant mutation in the amyloid precursor protein (APP) gene was described in 1991. Later, AD was also associated with mutated early-onset (presenilin 1/2, PSEN1/2 and APP) and late-onset (apolipoprotein E, ApoE) genes. Genome-wide association and linkage analysis studies with identified multiple genomic areas have implications for the treatment of AD. We conclude this review with future directions and clinical implications of genetic research in AD.
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https://hal.univ-lille.fr/hal-02468738
Contributeur : Lilloa Université de Lille <>
Soumis le : jeudi 6 février 2020 - 09:41:45
Dernière modification le : vendredi 7 février 2020 - 01:43:22

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UNIV-LILLE | SCALAB | CNRS

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Ahmed A. Moustafa, Mubashir Hassan, Doaa H. Hewedi, Iman Hewedi, Julia K. Garami, et al.. Genetic underpinnings in Alzheimer's disease - a review. Reviews in the Neurosciences, Walter de Gruyter, 2017, Reviews in the Neurosciences, 29 (1), pp.21-38. ⟨10.1515/revneuro-2017-0036⟩. ⟨hal-02468738⟩

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