Arrêt de service programmé du vendredi 10 juin 16h jusqu’au lundi 13 juin 9h. Pour en savoir plus
Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Safety of oral anticoagulants on experimental brain microbleeding and cognition

Abstract : This study aims at determining the ability of clinical-based doses of four oral anticoagulants to transform the onset of a cerebral microhemorrhages (CMH) burden into a symptomatic intracerebral hemorrhage (ICH) in the healthy brain, and precipitate cognitive impairment. Wild-type mice were anticoagulated for 10 days using apixaban, rivaroxaban or dabigatran as direct oral anticoagulants (DOACs), or warfarin as vitamin K-antagonist. Meanwhile, a burden of ∼20 CMHs was induced in the Sylvian territory by intra-carotid injection of cyclodextrin nanoparticles. At bleeding onset, only warfarin provoked deadly hematoma, and dramatically increased mortality (+45%). All the DOACs enhanced CMH burden through a greater number of intermediate-sized microhemorrhages (+80% to +180%). Although silent at onset, both baseline- and anticoagulant-enhanced CMH burdens increased mortality (+11% to +58%) along the following year without statistical difference among groups, and despite cessation of anticoagulation and absence of CMH progression or transformation into ICH. All survivor mice exhibited reduction in visual recognition memory from 9 months. In the healthy brain, DOACs preserve the onset of microhemorrhages from transformation into ICH, and do not precipitate cognitive impairment despite enhancement of CMH burden. High CMH burdens should however be considered for early detection and preventive memory care apart from anticoagulation decisions.
Type de document :
Article dans une revue
Liste complète des métadonnées

Littérature citée [40 références]  Voir  Masquer  Télécharger
Contributeur : Lilloa Université de Lille Connectez-vous pour contacter le contributeur
Soumis le : jeudi 13 février 2020 - 10:57:00
Dernière modification le : mercredi 23 mars 2022 - 15:51:22
Archivage à long terme le : : jeudi 14 mai 2020 - 13:55:45


Fichiers éditeurs autorisés sur une archive ouverte


Distributed under a Creative Commons Paternité 4.0 International License




Maud Petrault, Thavarak Ouk, Olivier Petrault, Michele Bastide, Regis Bordet, et al.. Safety of oral anticoagulants on experimental brain microbleeding and cognition. Neuropharmacology, Elsevier, 2019, Neuropharmacology, 155, pp.162-172. ⟨10.1016/j.neuropharm.2019.05.030⟩. ⟨hal-02477123⟩



Consultations de la notice


Téléchargements de fichiers