Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Efficiency of hydrogen peroxide in improving disinfection of ICU rooms

Abstract : BACKGROUND: The primary objective of this study was to determine the efficiency of hydrogen peroxide (H₂O₂) techniques in disinfection of ICU rooms contaminated with multidrug-resistant organisms (MDRO) after patient discharge. Secondary objectives included comparison of the efficiency of a vaporizator (HPV, Bioquell) and an aerosolizer using H₂O₂, and peracetic acid (aHPP, Anios) in MDRO environmental disinfection, and assessment of toxicity of these techniques. METHODS: This prospective cross-over study was conducted in five medical and surgical ICUs located in one University hospital, during a 12-week period. Routine terminal cleaning was followed by H₂O₂ disinfection. A total of 24 environmental bacteriological samplings were collected per room, from eight frequently touched surfaces, at three time-points: after patient discharge (T0), after terminal cleaning (T1) and after H₂O₂ disinfection (T2). RESULTS: In total 182 rooms were studied, including 89 (49%) disinfected with aHPP and 93 (51%) with HPV. At T0, 15/182 (8%) rooms were contaminated with at least 1 MDRO (extended spectrum β-lactamase-producing Gram-negative bacilli 50%, imipenem resistant Acinetobacter baumannii 29%, methicillin-resistant Staphylococcus aureus 17%, and Pseudomonas aeruginosa resistant to ceftazidime or imipenem 4%). Routine terminal cleaning reduced environmental bacterial load (P <0.001) without efficiency on MDRO (15/182 (8%) rooms at T0 versus 11/182 (6%) at T1; P = 0.371). H₂O₂ technologies were efficient for environmental MDRO decontamination (6% of rooms contaminated with MDRO at T1 versus 0.5% at T2, P = 0.004). Patient characteristics were similar in aHPP and HPV groups. No significant difference was found between aHPP and HPV regarding the rate of rooms contaminated with MDRO at T2 (P = 0.313). 42% of room occupants were MDRO carriers. The highest rate of rooms contaminated with MDRO was found in rooms where patients stayed for a longer period of time, and where a patient with MDRO was hospitalized. The residual concentration of H₂O₂ appears to be higher using aHPP, compared with HPV. CONCLUSIONS: H₂O₂ treatment is efficient in reducing MDRO contaminated rooms in the ICU. No significant difference was found between aHPP and HPV regarding their disinfection efficiency.
Type de document :
Article dans une revue
Liste complète des métadonnées

Littérature citée [35 références]  Voir  Masquer  Télécharger

https://hal.univ-lille.fr/hal-02517594
Contributeur : Lilloa Université de Lille <>
Soumis le : mardi 24 mars 2020 - 16:30:53
Dernière modification le : mercredi 6 mai 2020 - 19:44:01

Fichier

2015 CC Hydrogen Peroxide.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Licence


Distributed under a Creative Commons Paternité - Pas d'utilisation commerciale 4.0 International License

Identifiants

Collections

Citation

Caroline Blazejewski, Frederic Wallet, Anahita Rouze, Rémi Le Guern, Sylvie Ponthieux, et al.. Efficiency of hydrogen peroxide in improving disinfection of ICU rooms. Critical Care, BioMed Central, 2015, 19, pp.30. ⟨10.1186/s13054-015-0752-9⟩. ⟨hal-02517594⟩

Partager

Métriques

Consultations de la notice

245

Téléchargements de fichiers

677