Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Donor caveolin 1 (cav1) genetic polymorphism influences graft function after renal transplantation

Abstract : BACKGROUND: Identification of the culprit genes underlying multifactorial diseases is one of the most important current challenges of molecular genetics. While recent advances in genomics research have accelerated the discovery of susceptibility genes, much remains to be learned about the functions of disease-associated genetic variants. Recently, Moore and co-workers identified, in the donor genome, an association between a common genetic variant (rs4730751) in the gene encoding caveolin-1 (CAV1), a major structural component of caveolae, and long-term allograft survival. METHODS: Four hundred seventy-five renal recipients consecutively transplanted were included in this study. Donor genomic DNA was extracted and used to genotype CAV1 rs4730751 Single Nucleotide Polymorphism. RESULTS: Patients receiving a graft carrying CAV1 rs4730751 AA genotype displayed a significant decrease in estimated glomerular filtration rate and a significant increase in serum creatinine in both univariate and multivariate analyzes. Moreover, patients receiving a graft with CAV1 AA genotype significantly developed more interstitial fibrosis lesions on systematic biopsies performed 3 months post-transplantation. CONCLUSIONS: Genotyping of CAV1 may be relevant to identify patients at risk of adverse renal transplant outcome.
Liste complète des métadonnées

Littérature citée [24 références]  Voir  Masquer  Télécharger

https://hal.univ-lille.fr/hal-02519627
Contributeur : Lilloa Université de Lille <>
Soumis le : jeudi 26 mars 2020 - 10:58:15
Dernière modification le : mardi 20 octobre 2020 - 03:28:35
Archivage à long terme le : : samedi 27 juin 2020 - 13:22:33

Fichier

s41598-017-12955-7.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Licence


Distributed under a Creative Commons Paternité 4.0 International License

Identifiants

Collections

Citation

Cynthia van der Hauwaert, Gregoire Savary, Viviane Gnemmi, Christian Noel, Franck Broly, et al.. Donor caveolin 1 (cav1) genetic polymorphism influences graft function after renal transplantation. Fibrogenesis and Tissue Repair, BioMed Central, 2015, 8, pp.8. ⟨10.1186/s13069-015-0025-x⟩. ⟨hal-02519627⟩

Partager

Métriques

Consultations de la notice

253

Téléchargements de fichiers

638