A. M. Ferreira and Y. Sakr, Organ dysfunction: general approach, epidemiology, and organ failure scores, Semin Respir Crit Care Med, vol.32, pp.543-51, 2011.

P. Cengiz and J. J. Zimmerman, Prelude to pediatric multiple organ dysfunction syndrome: the golden hours concept revisited, Pediatr Crit Care Med, vol.4, pp.263-267, 2003.

J. C. Marshall, J. L. Vincent, G. Guyatt, D. C. Angus, A. E. Bernard et al., Outcome measures for clinical research in sepsis: a report of the 2nd

, Cambridge Colloquium of the International Sepsis Forum, Crit Care Med, vol.33, pp.1708-1724, 2005.

F. Proulx, M. Gauthier, D. Nadeau, J. Lacroix, and C. A. Farrell, Timing and predictors of death in pediatric patients with multiple organ system failure, Crit Care Med, vol.22, pp.1025-1056, 1994.

J. D. Wilkinson, M. M. Pollack, N. L. Glass, R. K. Kanter, R. W. Katz et al., Mortality associated with multiple organ system failure and sepsis in pediatric intensive care unit, J Pediatr, vol.111, pp.324-332, 1987.

J. Johnston, M. Yi, M. Britto, and J. Mrus, Importance of organ dysfunction in determining hospital outcomes in children, J Pediatr, vol.144, pp.595-601, 2004.

J. Tantalean, R. Leon, A. Santos, and E. Sanchez, Multiple organ dysfunction syndrome in children, Pediatr Crit Care Med, vol.4, pp.181-186, 2003.

F. Leclerc, S. Leteurtre, A. Duhamel, B. Grandbastien, F. Proulx et al., Cumulative influence of organ dysfunctions and septic state on mortality of critically ill children, Am J Respir Crit Care Med, vol.171, pp.348-53, 2005.

J. L. Vincent and R. Moreno, Clinical review: scoring systems in the critically ill, Crit Care, vol.14, p.207, 2010.

J. Lacroix and J. Cotting, Severity of illness and organ dysfunction scoring in children, Pediatr Crit Care Med, vol.6, pp.126-160, 2005.

E. Sevketoglu, D. Yildizdas, O. O. Horoz, H. S. Kihtir, T. Kendirli et al., Use of therapeutic plasma exchange in children with thrombocytopenia-associated multiple organ failure in the Turkish thrombocytopenia-associated multiple organ failure network, Pediatr Crit Care Med, vol.15, pp.354-363, 2014.

S. Leteurtre, A. Duhamel, B. Grandbastien, J. Lacroix, and F. Leclerc, Paediatric logistic organ dysfunction (PELOD) score, Lancet, vol.367, pp.900-892, 2006.

S. Leteurtre, A. Duhamel, B. Grandbastien, F. Proulx, J. Cotting et al., Daily estimation of the severity of multiple organ dysfunction syndrome in critically ill children, CMAJ, vol.182, pp.1181-1188, 2010.

S. Leteurtre, A. Duhamel, J. Salleron, B. Grandbastien, J. Lacroix et al., PELOD-2: an update of the PEdiatric logistic organ dysfunction score, Crit Care Med, vol.41, pp.1761-73, 2013.

F. L. Ferreira, D. P. Bota, A. Bross, C. Melot, and J. L. Vincent, Serial evaluation of the SOFA score to predict outcome in critically ill patients, JAMA, vol.286, pp.1754-1762, 2001.

D. A. Zygun, K. B. Laupland, G. H. Fick, J. D. Sandham, and C. J. Doig, Limited ability of SOFA and MOD scores to discriminate outcome: a prospective evaluation in 1,436 patients, Can JAnaesth, vol.52, pp.302-310, 2005.

P. G. Metnitz, T. Lang, A. Valentin, H. Steltzer, C. G. Krenn et al., Evaluation of the logistic organ dysfunction system for the assessment of organ dysfunction and mortality in critically ill patients, Intensive Care Med, vol.27, pp.992-1000, 2001.

J. F. Timsit, J. P. Fosse, G. Troche, A. De-lassence, C. Alberti et al., Calibration and discrimination by daily Logistic Organ Dysfunction scoring comparatively with daily Sequential Organ Failure Assessment scoring for predicting hospital mortality in critically ill patients, Crit Care Med, vol.30, pp.2003-2016, 2002.

J. L. Vincent, A. De-mendonca, F. Cantraine, R. Moreno, J. Takala et al., Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine, Crit Care Med, vol.26, pp.1793-800, 1998.

S. Leteurtre, A. Martinot, A. Duhamel, F. Proulx, B. Grandbastien et al., Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study, Lancet, vol.362, pp.192-199, 2003.

S. B. Cappi, Y. Sakr, and J. L. Vincent, Daily evaluation of organ function during renal replacement therapy in intensive care unit patients with acute renal failure, J Crit Care, vol.21, pp.179-83, 2006.

R. Cook, D. Cook, J. Tilley, K. Lee, and J. Marshall, Multiple organ dysfunction: baseline and serial component scores, Crit Care Med, vol.29, pp.2046-50, 2001.

C. J. Doig, D. A. Zygun, G. H. Fick, K. B. Laupland, P. J. Boiteau et al., Study of clinical course of organ dysfunction in intensive care, Crit Care Med, vol.32, pp.384-90, 2004.

S. Jacobs, M. Zuleika, and T. Mphansa, The Multiple Organ Dysfunction Score as a descriptor of patient outcome in septic shock compared with two other scoring systems, Crit Care Med, vol.27, pp.741-745, 1999.

A. Junger, J. Engel, M. Benson, S. Bottger, C. Grabow et al., Discriminative power on mortality of a modified Sequential Organ Failure Assessment score for complete automatic computation in an operative intensive care unit, Crit Care Med, vol.30, pp.338-380, 2002.

Y. A. Kilic, K. Yorganci, and I. Sayek, Visualizing multiple organ failure: a method for analyzing temporal and dynamic relations between failing systems and interventions, Crit Care, vol.11, p.417, 2007.

R. Moreno, J. L. Vincent, R. Matos, A. Mendonca, F. Cantraine et al., The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of a prospective, multicentre study. Working Group on Sepsis related Problems of the ESICM, Intensive Care Med, vol.25, pp.686-96, 1999.

R. B. Thandassery, T. D. Yadav, U. Dutta, S. Appasani, K. Singh et al., Dynamic nature of organ failure in severe acute pancreatitis: the impact of persistent and deteriorating organ failure, HPB, vol.15, pp.523-531, 2013.

M. Darmon, E. Azoulay, G. Thiery, M. Ciroldi, L. Galicier et al., Time course of organ dysfunction in thrombotic microangiopathy patients receiving either plasma perfusion or plasma exchange, Crit Care Med, vol.34, pp.2127-2160, 2006.

J. Lacroix, P. C. Hebert, J. S. Hutchison, H. A. Hume, M. Tucci et al., Transfusion strategies for patients in pediatric intensive care units, N Engl J Med, vol.356, pp.1609-1628, 2007.

R. Rivera-fernandez, R. Nap, G. Vazquez-mata, R. Miranda, and D. , Analysis of physiologic alterations in intensive care unit patients and their relationship with mortality, J Crit Care, vol.22, pp.120-128, 2007.

J. L. Vincent, J. F. Baron, K. Reinhart, L. Gattinoni, L. Thijs et al., Anemia and blood transfusion in critically ill patients, JAMA, vol.288, pp.1499-507, 2002.

D. P. Wagner, W. A. Knaus, F. E. Harrell, J. E. Zimmerman, and C. Watts, Daily prognostic estimates for critically ill adults in intensive care units: results from a prospective, multicenter, inception cohort analysis, Crit Care Med, vol.22, pp.1359-72, 1994.

V. A. Ferraris and M. E. Propp, Outcome in critical care patients: a multivariate study, Crit Care Med, vol.20, pp.967-76, 1992.

J. C. Marshall, Measuring organ dysfunction in the intensive care unit: why and how?, Can J Anaesth, vol.52, pp.224-254, 2005.

A. J. Petros, J. C. Marshall, and H. K. Van-saene, Should morbidity replace mortality as an endpoint for clinical trials in intensive care?, Lancet, vol.345, pp.369-71, 1995.

T. C. Nguyen, Y. Y. Han, J. E. Kiss, M. W. Hall, A. C. Hassett et al., Intensive plasma exchange increases a disintegrin and metalloprotease with thrombospondin motifs-13 activity and reverses organ dysfunction in children with thrombocytopenia-associated multiple organ failure, Crit Care Med, vol.36, pp.2878-87, 2008.

S. L. Weiss, J. C. Fitzgerald, F. Balamuth, E. R. Alpern, J. Lavelle et al., Delayed antimicrobial therapy increases mortality and organ dysfunction duration in pediatric sepsis, Crit Care Med, vol.42, pp.2409-2426, 2014.

M. Sandri, P. Berchialla, I. Baldi, D. Gregori, D. Blasi et al., Dynamic Bayesian Networks to predict sequences of organ failures in patients admitted to ICU, J Biomed Inform, vol.48, pp.106-119, 2014.

J. P. Burns, D. E. Sellers, E. C. Meyer, M. Lewis-newby, and R. D. Truog, Epidemiology of death in the PICU at five U.S. teaching hospitals*, Crit Care Med, vol.42, pp.2101-2109, 2014.

J. P. Goncalves, M. Severo, C. Rocha, J. Jardim, T. Mota et al., Performance of PRISM III and PELOD-2 scores in a pediatric intensive care unit, Eur J Pediatr, 2015.