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Bile Diversion in Roux-en-Y Gastric Bypass Modulates Sodium-Dependent Glucose Intestinal Uptake

Abstract : Gastro-intestinal exclusion by Roux-en-Y gastric bypass (RYGB) improves glucose metabolism, independent of weight loss. Although changes in intestinal bile trafficking have been shown to play a role, the underlying mechanisms are unclear. We performed RYGB in minipigs and showed that the intestinal uptake of ingested glucose is blunted in the bile-deprived alimentary limb (AL). Glucose uptake in the AL was restored by the addition of bile, and this effect was abolished when active glucose intestinal transport was blocked with phlorizin. Sodium-glucose cotransporter 1 remained expressed in the AL, while intraluminal sodium content was markedly decreased. Adding sodium to the AL had the same effect as bile on glucose uptake. It also increased postprandial blood glucose response in conscious minipigs following RYGB. The decrease in intestinal uptake of glucose after RYGB was confirmed in humans. Our results demonstrate that bile diversion affects postprandial glucose metabolism by modulating sodium-glucose intestinal cotransport.
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https://hal.univ-lille.fr/hal-02543230
Contributeur : Lilloa Université de Lille <>
Soumis le : mercredi 15 avril 2020 - 11:00:45
Dernière modification le : lundi 27 avril 2020 - 10:37:55

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Gregory Baud, Mehdi Daoudi, Thomas Hubert, Violeta Raverdy, Marie Pigeyre, et al.. Bile Diversion in Roux-en-Y Gastric Bypass Modulates Sodium-Dependent Glucose Intestinal Uptake. Cell Metabolism, 2016, Cell Metabolism, 23 (3), pp.547-553. ⟨10.1016/j.cmet.2016.01.018⟩. ⟨hal-02543230⟩

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