, Infectious Diseases Department, Gustave Dron Hospital of Tourcoing, 135 rue du Président Coty, 59200 Tourcoing, France. 4 Unit of Infectious Diseases Hospital 12 de Octubre of Madrid

, 12 Orthopaedic Surgery Unit, University Hospital of Caen, Orthopaedic Surgery Unit, p.14

, Faculty Hospital of Lille

W. Zimmerli, A. Trampuz, and P. E. Ochsner, Prosthetic-joint infections, N Engl J Med, vol.351, pp.1645-54, 2004.

S. M. Odum, T. K. Fehring, A. V. Lombardi, B. M. Zmistowski, N. M. Brown et al., Irrigation and debridement for periprosthetic infections: does the organism matter?, J Arthroplasty, vol.26, pp.114-122, 2011.

A. M. Meehan, D. R. Osmon, M. C. Duffy, A. D. Hanssen, and M. R. Keating, Outcome of penicillin susceptible streptococcal prosthetic joint infection treated with debridement and retention of the prosthesis, Clin Infect Dis, vol.36, pp.845-894, 2003.

R. J. Everts, S. T. Chambers, D. R. Murdoch, A. G. Rothwell, and J. Mckie, Successful antimicrobial therapy and implant retention for streptococcal infection of prosthetic joints, ANZ J Surg, vol.74, pp.210-224, 2004.

M. Betz, S. Abrassart, P. Vaudaux, E. Gjika, M. Schindler et al., Increased risk of joint failure in hip prostheses infected with Staphylococcus aureus with debridement, antibiotics and implant retention compared to Streptococcus spp, Int Orthop, vol.39, pp.397-401, 2015.

V. Zeller, M. Lavigne, D. Biau, P. Leclerc, J. M. Ziza et al., Outcome of group B streptococcal prosthetic hip infections compared to that of other bacterial infections, Jt Bone Spine Rev Rhum, vol.76, pp.491-497, 2009.

D. R. Osmon, E. F. Berbari, A. R. Berendt, D. Lew, W. Zimmerli et al., Infectious Diseases Society of America. Executive summary: diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America, Clin Infect Dis, vol.56, pp.1-10, 2013.

P. Gilbert, P. J. Collier, and M. R. Brown, Influence of growth rate on susceptibility to antimicrobial agents: biofilms, cell cycle, dormancy, and stringent response, Antimicrob Agents Chemother, vol.34, pp.1865-1873, 1990.

W. Zimmerli, A. Widmer, M. Blatter, R. Frei, and P. E. Ochsner, Role of rifampin for treatment of orthopedic implant-related staphylococcal infections: a randomized controlled trial. Foreign-Body Infection (FBI) Study Group, JAMA, vol.279, pp.1537-1578, 1998.

O. C. El-helou, E. F. Berbari, B. D. Lahr, J. E. Eckel-passow, R. R. Razonable et al., Effectiveness and safety of rifampicin containing regimen for staphylococcal prosthetic joint infections treated with debridement and retention, Eur J Clin Microbiol Infect Dis, vol.29, pp.961-968, 2010.

E. Senneville, D. Joulie, L. Legout, M. Valette, H. Dezèque et al., Outcome and predictors of treatment failure in total hip/knee prosthetic joint infections due to Staphylococcus aureus, Clin Infect Dis, vol.53, pp.334-374, 2011.

J. Lora-tamayo, O. Murillo, J. A. Iribarren, A. Soriano, M. Sanchez-somolinos et al., A large multicenter study of methicillin-susceptible and methicillin-resistant Staphylococcus aureus prosthetic joint infections managed with implant retention, Clin Infect Dis, vol.56, p.182194, 2013.

A. Trampuz, C. Perka, and O. Borens, Prosthetic joint infection: new developments in diagnosis and treatment, Dtsch Med Wochenschr, vol.138, pp.1571-1574, 2013.

E. Boselli and B. Allaouchiche, Diffusion in bone tissue of antibiotics, Presse Med, vol.28, pp.2265-76, 1999.

G. N. Forrest and K. Tamura, Rifampicin combination therapy for nonmycobacterial infections, Clin Microbiol Rev, vol.23, pp.14-34, 2010.

J. Parvizi, T. Gehrke, and A. F. Chen, Proceedings of the International Consensus on Periprosthetic Joint Infection, vol.95, pp.1450-1452, 2013.

A. Holmberg, M. Morgelin, and M. Rasmussen, Effectiveness of ciprofloxacin or linezolid in combination with rifampicin against Enterococcus faecalis in biofilms, J Antimicrob Chemother, vol.67, pp.433-442, 2012.

L. Zürcher-pfund, I. Uçkay, L. Legout, A. Gamulin, P. Vaudaux et al., Pathogen-driven decision for implant retention in the management of infected total knee prostheses, Int Orthop, vol.37, pp.1471-1476, 2013.

P. Sendi, B. Christensson, I. Uçkay, A. Trampuz, Y. Achermann et al., BGS PJI study group. Group B streptococcus in prosthetic hip and knee joint-associated infections, J Hosp Infect, vol.79, pp.64-73, 2011.

J. M. Duggan, G. Georgiadis, C. Vangorp, and J. Kleshinski, Group B streptococcal prosthetic joint infections, J South Orthop Assoc, vol.10, pp.209-223, 2001.

E. Tornero, E. Senneville, G. Euba, S. Petersdorf, D. Rodriguez-pardo et al., Characteristics of prosthetic joint infections due to Enterococcus sp and predictors of failure: a multi-national study, European Society Group of Infections on Artificial Implants (ESGIAI), vol.11, pp.1219-1243, 2014.

G. Pasquantonio, S. Condo, L. Cerroni, L. Bikiqu, M. Nicoletti et al., Antibacterial activity of various antibiotics against oral streptococci isolated in the oral cavity, Int J Immunopathol Pharmacol, vol.25, pp.805-814, 2012.

J. J. Vesely, F. D. Pien, and B. C. Pien, Rifampicin, a useful drug for nonmycobacterial infections, Pharmacotherapy, vol.18, pp.345-57, 1998.

L. T. Buller, F. Y. Sabry, R. W. Easton, A. K. Klika, and W. K. Barsoum, The preoperative prediction of success following irrigation and debridement with polyethylene exchange for hip and knee prosthetic joint infections, J Arthroplasty, vol.27, pp.757-854, 2012.

F. Vilchez, J. C. Martínez-pastor, S. García-ramiro, G. Bori, F. Maculé et al., Efficacy of debridement in hematogenous and early post-surgical prosthetic joint infections, Int J Artif Organs, vol.34, pp.863-872, 2011.

D. Rodríguez, C. Pigrau, G. Euba, J. Cobo, J. García-lechuz et al., Acute haematogenous prosthetic joint infection: prospective evaluation of medical and surgical management, Clin Microbiol Infect, vol.16, pp.1789-95, 2010.

, Osteo-articular infection therapy according to materials used (prosthesis, implants, osteosynthesis)

, Groupe de Pathologie Infectieuse Pédiatrique (GPIP

, Société Française d'Anesthésie et de Réanimation (SFAR)

. Société-française-de, Chirurgie Orthopédique et Traumatologique (SOFCOT

, Société Française d'Hygiène Hospitalière (SFHH)

, Société Française de Médecine Physique et de Réadaptation (SOFMER)

, Société Française de Microbiologie (SFM

. Sfr-rhu, Société rançaise de Rhumatologie, vol.39, pp.745-74, 2009.

S. Nguyen, O. Robineau, M. Titecat, N. Blondiaux, M. Valette et al., Influence of daily dosage and frequency of administration of rifampicinlevofloxacin therapy on tolerance and effectiveness in 154 patients treated for prosthetic joint infections, Eur J Clin Microbiol Infect Dis, vol.4, pp.1675-82, 2015.

W. Zimmerli, R. Frei, A. F. Widmer, and Z. Rajacic, Microbiological tests to predict treatment outcome in experimental device-related infections due to Staphylococcus aureus, J Antimicrob Chemother, vol.33, pp.959-67, 1994.