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Factors generating glucose degradation products in sterile glucose solutions for infusion: statistical relevance determination of their impacts

Abstract : Sterilising glucose solutions by heat promotes the generation of a large number of glucose degradation products (GDPs). It has been shown that high levels of GDPs may result in Advanced Glycation End products that have an impact on cellular homeostasis and health in general. If data is available for peritoneal dialysis solutions, little has been published for glucose infusion fluids. It is essential to identify the parameters causing the formation of GDPs and so limit the risk of exposing patients to them. After quantifying both 5-hydroxymethyl-2-furfural, considered as an important indicator of degradation, and 2-furaldehyde, an ultimate GDP of one degradation pathway, in marketed solutions, the aim of this work is to build a model integrating all the parameters involved in the formation rates of these two GDPs: supplier, glucose amount, container material, oxygen permeability coefficient and time-lapse since manufacture. Our results show a good logarithmic relationship between GDP formation rates and time-lapse since manufacture for both GDPs. The amount of GDPs in the glucose solutions for infusion depends on the initial glucose amount, the polymer of the container, the time elapsed since manufacturing and the supplier.
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https://hal.univ-lille.fr/hal-02612446
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Soumis le : mardi 19 mai 2020 - 10:48:07
Dernière modification le : lundi 25 mai 2020 - 12:40:22

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J. Haybrard, Nicolas Simon, Cecile Danel, Claire Pinçon, Christine Barthelemy, et al.. Factors generating glucose degradation products in sterile glucose solutions for infusion: statistical relevance determination of their impacts. Scientific Reports, Nature Publishing Group, 2017, Scientific reports, 7 (1), ⟨10.1038/s41598-017-12296-5⟩. ⟨hal-02612446⟩

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