Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Vaginal mucosal homeostatic response may determine pregnancy outcome in women with bacterial vaginosis a pilot study

Abstract : Bacterial vaginosis (BV) is considered as a trigger for an inflammatory response that could promote adverse pregnancy outcome (APO). We hypothesized that BV-related inflammation could be counterbalanced by anti-inflammatory and mucosal homeostatic responses that could participate in pregnancy outcomes.A total of 402 vaginal self-samples from pregnant women in their first trimester were screened by Nugent score. In this population, we enrolled 23 pregnant women with BV but without APO, 5 pregnant women with BV and developing APO, 21 pregnant women with intermediate flora, and 28 random control samples from pregnant women without BV or APO.BV without APO in pregnant women was associated with 28-fold interleukin-8, 5-fold interleukin-10, and 40-fold interleukin-22 increases in expression compared to controls. BV associated with APO in pregnant women shared 4-fold increase in tumor necrosis factor, 100-fold decrease in interleukin-10, and no variation in interleukin-22 expressions compared to controls. Next-generation sequencing of vaginal microbiota revealed a shift from obligate anaerobic bacteria dominance in BV without APO pregnant women to Lactobacillus dominance microbiota in BV with APO.Our results show that the anti-inflammatory and mucosal homeostatic responses to BV may determine outcome of pregnancy in the setting of BV possibly through effects on the vaginal microbiota.
Type de document :
Article dans une revue
Liste complète des métadonnées

Littérature citée [30 références]  Voir  Masquer  Télécharger

https://hal.univ-lille.fr/hal-02617032
Contributeur : Lilloa Université de Lille <>
Soumis le : lundi 25 mai 2020 - 09:31:59
Dernière modification le : lundi 1 juin 2020 - 11:51:58

Fichier

Vaginal_Mucosal_Homeostatic_Re...
Fichiers éditeurs autorisés sur une archive ouverte

Licence


Distributed under a Creative Commons Paternité 4.0 International License

Identifiants

Collections

Citation

Emmanuel Faure, Karine Faure, Martin Figeac, Eric Kipnis, Teddy Grandjean, et al.. Vaginal mucosal homeostatic response may determine pregnancy outcome in women with bacterial vaginosis a pilot study. Medicine, Lippincott, Williams & Wilkins, 2016, Medicine, 95, ⟨10.1097/MD.0000000000002668⟩. ⟨hal-02617032⟩

Partager

Métriques

Consultations de la notice

15

Téléchargements de fichiers

19