R. P. Dellinger, M. M. Levy, A. Rhodes, D. Annane, H. Gerlach et al., Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, Intensive Care Med, vol.39, issue.2, pp.165-228, 2012.

M. Singer, C. S. Deutschman, C. W. Seymour, M. Shankar-hari, D. Annane et al., The third international consensus definitions for sepsis and septic shock (Sepsis-3), JAMA, vol.315, issue.8, pp.801-811, 2016.

D. C. Angus and T. Van-der-poll, Severe sepsis and septic shock, N Engl J Med, vol.369, issue.9, pp.840-51, 2013.

J. R. Nofer, B. Kehrel, M. Fobker, B. Levkau, G. Assmann et al., HDL and arteriosclerosis: beyond reverse cholesterol transport. Atherosclerosis, vol.161, pp.1-16, 2002.

M. T. Cooney, A. Dudina, D. Bacquer, D. Wilhelmsen, L. Sans et al., HDL cholesterol protects against cardiovascular disease in both genders, at all ages and at all levels of risk, Atherosclerosis, vol.206, issue.2, pp.611-617, 2009.

G. D. Norata, A. Pirillo, E. Ammirati, and A. L. Catapano, Emerging role of high density lipoproteins as a player in the immune system, Atherosclerosis, vol.220, issue.1, pp.11-21, 2012.

A. Tran-dinh, D. Diallo, S. Delbosc, L. M. Varela-perez, Q. B. Dang et al., HDL and endothelial protection, Br J Pharmacol, vol.169, issue.3, pp.493-511, 2013.

M. C. Mcdonald, P. Dhadly, G. W. Cockerill, S. Cuzzocrea, H. Mota-filipe et al., Reconstituted high-density lipoprotein attenuates organ injury and adhesion molecule expression in a rodent model of endotoxic shock, Shock, vol.20, issue.6, pp.551-558, 2003.

L. Dai, G. Datta, Z. Zhang, H. Gupta, R. Patel et al., The apolipoprotein A-I mimetic peptide 4F prevents defects in vascular function in endotoxemic rats, J Lipid Res, vol.51, issue.9, pp.2695-705, 2010.

Z. Zhang, G. Datta, Y. Zhang, A. P. Miller, P. Mochon et al., Apolipoprotein A-I mimetic peptide treatment inhibits inflammatory responses and improves survival in septic rats, Am J Physiol Heart Circ Physiol, vol.297, issue.2, pp.866-73, 2009.

H. Gupta, L. Dai, G. Datta, D. W. Garber, H. Grenett et al., Inhibition of lipopolysaccharideinduced inflammatory responses by an apolipoprotein AI mimetic peptide, Circ Res, vol.97, issue.3, pp.236-279, 2005.

X. Zhang, L. Wang, and B. Chen, Recombinant HDL (Milano) protects endotoxin-challenged rats from multiple organ injury and dysfunction, Biol Chem, vol.396, issue.1, pp.53-60, 2015.

H. J. Van-leeuwen, E. C. Heezius, G. M. Dallinga, J. A. Van-strijp, J. Verhoef et al., Lipoprotein metabolism in patients with severe sepsis, Crit Care Med, vol.31, issue.5, pp.1359-66, 2003.

J. Y. Chien, J. S. Jerng, C. J. Yu, and P. C. Yang, Low serum level of high-density lipoprotein cholesterol is a poor prognostic factor for severe sepsis, Crit Care Med, vol.33, issue.8, pp.1688-93, 2005.

S. Barlage, C. Gnewuch, G. Liebisch, Z. Wolf, F. X. Audebert et al., Changes in HDL-associated apolipoproteins relate to mortality in human sepsis and correlate to monocyte and platelet activation, Intensive Care Med, vol.35, issue.11, pp.1877-85, 2009.

J. Hazeldine, P. Hampson, and J. M. Lord, The impact of trauma on neutrophil function, Injury, vol.45, issue.12, pp.1824-1857, 2014.

J. Pugin, How tissue injury alarms the immune system and causes a systemic inflammatory response syndrome, Ann Intensive Care, vol.2, issue.1, p.27, 2012.

J. M. Lord, M. J. Midwinter, Y. F. Chen, A. Belli, K. Brohi et al., The systemic immune response to trauma: an overview of pathophysiology and treatment, Lancet, vol.384, issue.9952, pp.1455-65, 2014.

J. L. Vincent, R. Moreno, J. Takala, S. Willatts, D. Mendonça et al., The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the working group on sepsis-related problems of the European society of intensive care medicine, Intensive Care Med, vol.22, issue.7, pp.707-717, 1996.

M. Antonelli, R. Moreno, J. L. Vincent, C. L. Sprung, A. Mendoça et al., Application of SOFA score to trauma patients. Sequential organ failure assessment, Intensive Care Med, vol.25, issue.4, pp.389-94, 1999.

S. P. Baker, B. O'neill, W. Haddon, and W. B. Long, The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care, J Trauma, vol.14, issue.3, pp.187-96, 1974.

L. M. Lavange and G. G. Koch, Rank score tests, Circulation, vol.114, issue.23, pp.2528-2561, 2006.

A. Pirillo, A. L. Catapano, and G. D. Norata, HDL in infectious diseases and sepsis, Handb Exp Pharmacol, vol.224, pp.483-508, 2015.

B. R. Gordon, T. S. Parker, D. M. Levine, S. D. Saal, J. C. Wang et al., Relationship of hypolipidemia to cytokine concentrations and outcomes in critically ill surgical patients, Crit Care Med, vol.29, issue.8, pp.1563-1571, 2001.

C. J. Vesy, R. L. Kitchens, G. Wolfbauer, J. J. Albers, and R. S. Munford, Lipopolysaccharide-binding protein and phospholipid transfer protein release lipopolysaccharides from gram-negative bacterial membranes, Infect Immun, vol.68, issue.5, pp.2410-2417, 2000.

M. M. Wurfel, S. T. Kunitake, H. Lichenstein, J. P. Kane, and S. D. Wright, Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS, J Exp Med, vol.180, issue.3, pp.1025-1060, 1994.

A. Lenz, G. A. Franklin, and W. G. Cheadle, Systemic inflammation after trauma, Injury, vol.38, issue.12, pp.1336-1381, 2007.

A. M. Binkowska, G. Michalak, and R. Slotwinski, Current views on the mechanisms of immune responses to trauma and infection, Cent Eur J Immunol, vol.40, issue.2, pp.206-222, 2015.

Q. Zhang, M. Raoof, Y. Chen, Y. Sumi, T. Sursal et al., Circulating mitochondrial DAMPs cause inflammatory responses to injury, Nature, vol.464, issue.7285, pp.104-111, 2010.

J. Seok, H. S. Warren, A. G. Cuenca, M. N. Mindrinos, H. V. Baker et al., Genomic responses in mouse models poorly mimic human inflammatory diseases, Proc Natl Acad Sci, vol.110, issue.9, pp.3507-3519, 2013.

O. Gilbert, J. R. Croffoot, A. J. Taylor, M. Nash, K. Schomer et al., Serum lipid concentrations among persons with spinal cord injury-a systematic review and meta-analysis of the literature, Atherosclerosis, vol.232, issue.2, pp.305-317, 2014.

S. H. Lee, M. S. Park, B. H. Park, W. J. Jung, I. S. Lee et al., Prognostic implications of serum lipid metabolism over time during sepsis, Biomed Res Int, p.789298, 2015.

M. Cirstea, K. R. Walley, J. A. Russell, L. R. Brunham, K. R. Genga et al., Decreased high-density lipoprotein cholesterol level is an early prognostic marker for organ dysfunction and death in patients with suspected sepsis, J Crit Care, vol.38, pp.289-94, 2017.

F. L. Ferreira, D. P. Bota, A. Bross, C. Mélot, and J. L. Vincent, Serial evaluation of the SOFA score to predict outcome in critically ill patients, JAMA, vol.286, issue.14, pp.1754-1762, 2001.

B. L. Heitmann, The effects of gender and age on associations between blood lipid levels and obesity in Danish men and women aged 35-65 years, J Clin Epidemiol, vol.45, issue.7, pp.693-702, 1992.

G. Heiss, I. Tamir, C. E. Davis, H. A. Tyroler, B. M. Rifkand et al., Lipoprotein-cholesterol distributions in selected North American populations: the lipid research clinics program prevalence study, Circulation, vol.61, issue.2, pp.302-317, 1980.

R. D. Abbott, R. J. Garrison, P. W. Wilson, F. H. Epstein, W. P. Castelli et al., Joint distribution of lipoprotein cholesterol classes. The Framingham study, Arterioscler Dallas Tex, vol.3, issue.3, pp.260-72, 1983.

P. W. Wilson, K. M. Anderson, T. Harris, W. B. Kannel, and W. P. Castelli, Determinants of change in total cholesterol and HDL-C with age: the Framingham Study, J Gerontol, vol.49, issue.6, pp.252-259, 1994.