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Best practices for the management of local-regional recurrent chordoma: a position paper by the chordoma global consensus group

A. Gronchi 1 P. Fossati 2 T. Akiyama 3 C. Alapetite 4 M. Baumann 5 Jean-Yves Blay 6 S. Bolle 7 S. Boriani P. Bruzzi 1 R. Capanna 8 A. Caraceni 1 R. Casadei V. Colia J. Debus 9 T. Delaney 10 A. Desai 11 P. Dileo 12 S. Dijkstra 13 F. Doglietto 14 A. Flanagan 15 S. Froelich 16 P A. Gardner 17 Hans Gelderblom 13 Z L. Gokaslan 18 R. Haas 19 C. Heery 20 N. Hindi 21 P. Hohenberger 22 F. Hornicek 23 R. Imai 24 L. Jeys 25 R L. Jones 26 Bernd Kasper 22 A. Kawai 27 M. Krengli 28 A. Leithner 29 I. Logowska 30 J. Martin Broto 21 D. Mazzatenta 1 C. Morosi 1 P. Nicolai 14 O J. Norum S. Patel 31 Nicolas Penel 32 P. Picci S. Pilotti 1 S. Radaelli 1 F. Ricchini 1 P. Rutkowski 30 S. Scheipl 33 C. Sen 34 E. Tamborini 1 K A. Thornton 23 B. Timmermann 35 V. Torri P U. Tunn 36 M. Uhl 22 Y. Yamada 37 D C. Weber 38 D. Vanel P P. Varga C La Vleggeert-Lankamp 39 Paolo Casali J. Sommer
Abstract : Chordomas are rare, malignant bone tumors of the skull-base and axial skeleton. Until recently, there was no consensus among experts regarding appropriate clinical management of chordoma, resulting in inconsistent care and suboptimal outcomes for many patients. To address this shortcoming, the European Society of Medical Oncology (ESMO) and the Chordoma Foundation, the global chordoma patient advocacy group, convened a multi-disciplinary group of chordoma specialists to define by consensus evidence-based best practices for the optimal approach to chordoma. In January 2015, the first recommendations of this group were published, covering the management of primary and metastatic chordomas. Additional evidence and further discussion were needed to develop recommendations about the management of local-regional failures. Thus, ESMO and CF convened a second consensus group meeting in November 2015 to address the treatment of locally relapsed chordoma. This meeting involved over 60 specialists from Europe, the United States and Japan with expertise in treatment of patients with chordoma. The consensus achieved during that meeting is the subject of the present publication and complements the recommendations of the first position paper.
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Contributeur : Lilloa Université de Lille <>
Soumis le : mercredi 18 novembre 2020 - 14:53:25
Dernière modification le : mercredi 9 juin 2021 - 16:02:06
Archivage à long terme le : : vendredi 19 février 2021 - 18:01:18


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A. Gronchi, P. Fossati, T. Akiyama, C. Alapetite, M. Baumann, et al.. Best practices for the management of local-regional recurrent chordoma: a position paper by the chordoma global consensus group. Annals of Oncology, Elsevier, 2017, Annals of oncology official journal of the European Society for Medical Oncology, 28, pp.1230-1242. ⟨10.1093/annonc/mdx054⟩. ⟨hal-02639001⟩



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