F. Gauvin, Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients, Transfusion, vol.50, issue.9, pp.1902-1915, 2010.

M. J. Fontaine, Age of blood as a limitation for transfusion: potential impact on blood inventory and availability, Transfusion, vol.50, issue.10, pp.2233-2242, 2010.

A. Tinmouth, Clinical consequences of red cell storage in the critically ill, Transfusion, vol.46, issue.11, pp.2014-2041, 2006.

P. C. Spinella, Warm fresh whole blood transfusion for severe hemorrhage: U. S. military and potential civilian applications, Crit Care Med, vol.36, issue.7, pp.340-345, 2008.

E. Bennett-guerrero, Evolution of adverse changes in stored RBCs, PNAS, vol.104, issue.43, pp.17063-17071, 2007.

C. R. Gilson, A novel mouse model of red blood cell storage and posttransfusion in vivo survival, Transfusion, vol.49, issue.8, pp.1546-53, 2009.

R. A. Middelburg, Storage time of blood products and transfusionrelated acute lung injury, Transfusion, vol.52, issue.3, pp.658-67, 2012.

J. R. Hess, Red cell changes during storage, Transfus Apher Sci, vol.43, issue.1, pp.51-60, 2010.

L. Van-de-watering, Red cell storage and prognosis, Vox Sang, vol.100, issue.1, pp.36-45, 2011.

S. A. Glynn, H. G. Klein, and P. M. Ness, The red blood cell storage lesion: the end of the beginning, Transfusion, vol.56, issue.6, pp.1462-1470, 2016.

E. A. Hod, R. O. Francis, and S. L. Spitalnik, Red blood cell storage lesion-induced adverse effects: more smoke; is there fire?, Anesth Analg, vol.124, issue.6, pp.1752-1756, 2017.

D. B. Kim-shapiro, J. Lee, and M. T. Gladwin, Storage lesion: role of red blood cell breakdown, Transfusion, vol.51, issue.4, pp.844-51, 2011.

A. Doctor, Hemoglobin conformation couples erythrocyte Snitrosothiol content to O2 gradients, Proc Natl Acad Sci U S A, vol.102, pp.5709-5723, 2005.

K. E. Remy, Transfusion of recently donated (fresh) red blood cells (RBCs) does not improve survival in comparison with current practice, while safety of the oldest stored units is yet to be established: a meta-analysis, Vox Sang, vol.111, issue.1, pp.43-54, 2016.

P. E. Alexander, Transfusion of fresher vs older red blood cells in hospitalized patients: a systematic review and meta-analysis, Blood, vol.127, issue.4, pp.400-410, 2016.

D. Wang, Transfusion of older stored blood and risk of death: a metaanalysis, Transfusion, vol.52, issue.6, pp.1184-95, 2012.

C. Aubron, Duration of red blood cells storage and outcome in critically ill patients, J Crit Care, vol.29, issue.3, pp.476-477, 2014.

K. E. Remy and P. C. Spinella, Red blood cell storage age-what we know from clinical trials, Expert Rev Hematol, vol.9, issue.11, pp.1011-1014, 2016.

S. J. Brunskill, Transfusion of fresher versus older red blood cells for all conditions, Cochrane Database Syst Rev, vol.5, p.10801, 2015.

C. Chai-adisaksopha, Mortality outcomes in patients transfused with fresher versus older red blood cells: a meta-analysis, Vox Sang, vol.112, issue.3, pp.268-78, 2017.

J. W. Eikelboom, Duration of red cell storage before transfusion and inhospital mortality, Am Heart J, vol.159, issue.5, pp.737-743, 2010.

G. Edgren, Duration of red blood cell storage and survival of transfused patients (CME), Transfusion, vol.50, issue.6, pp.1185-95, 2010.

O. Karam, Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study, Crit Care, vol.14, issue.2, p.57, 2010.

J. A. Weinberg, Duration of red cell storage influences mortality after trauma, J Trauma, vol.69, issue.6, pp.1427-1458, 2010.

P. C. Spinella, Does the storage duration of blood products affect outcomes in critically ill patients?, Transfusion, vol.51, issue.8, pp.1644-50, 2011.

R. A. Middelburg, L. M. Van-de-watering, and J. G. Van-der-bom, Blood transfusions: good or bad? Confounding by indication, an underestimated problem in clinical transfusion research, Transfusion, vol.50, issue.6, pp.1181-1184, 2010.

M. J. Vandromme, G. Mcgwin, and J. A. Weinberg, Blood transfusion in the critically ill: does storage age matter?, Scand J Trauma Resusc Emerg Med, vol.17, issue.1, p.35, 2009.

M. A. Blajchman, Clinical trial opportunities in transfusion medicine: proceedings of a National Heart, Lung, and Blood Institute State-of-the-Science Symposium, Transfus Med Rev, vol.24, issue.4, pp.259-85, 2010.

R. L. Sparrow, Red blood cell storage and transfusion-related immunomodulation, Blood Transfus, vol.8, issue.3, pp.26-30, 2010.

C. Lelubre, M. Piagnerelli, and J. L. Vincent, Association between duration of storage of transfused red blood cells and morbidity and mortality in adult patients: myth or reality?, Transfusion, vol.49, issue.7, pp.1384-94, 2009.

N. M. Heddle, Effect of short-term vs. long-term blood storage on mortality after transfusion, N Engl J Med, vol.375, issue.20, pp.1937-1982, 2016.

M. E. Steiner, Effects of red-cell storage duration on patients undergoing cardiac surgery, N Engl J Med, vol.372, issue.15, pp.1419-1448, 2015.

J. Lacroix, The ABLE study: a randomized controlled trial on the efficacy of fresh red cell units to improve the outcome of transfused critically ill adults, Transfus Clin Biol, vol.22, issue.3, pp.107-118, 2015.

D. J. Cooper, Age of red cells for transfusion and outcomes in critically ill adults, N Engl J Med, vol.377, pp.1858-67, 2017.

Z. K. Mcquilten, Effect of age of red cells for transfusion on patient outcomes: a systematic review and meta-analysis, Transfus Med Rev, vol.32, issue.2, pp.77-88, 2018.

A. Dhabangi, The effect of blood storage age on treatment of lactic acidosis by transfusion in children with severe malarial anaemia: a pilot, randomized, controlled trial, Malar J, vol.12, p.55, 2013.

D. A. Fergusson, Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: the ARIPI randomized trial, JAMA, vol.308, issue.14, pp.1443-51, 2012.

P. C. Spinella, Survey of transfusion policies at US and Canadian children's hospitals in, Transfusion, vol.50, issue.11, pp.2328-2363, 2008.

F. Proulx, Epidemiology of sepsis and multiple organ dysfunction syndrome in children, Chest, vol.109, pp.1033-1040, 1996.

S. Leteurtre, Daily estimation of the severity of organ dysfunctions in critically ill children by using the PELOD-2 score, Crit Care, vol.19, p.324, 2015.
URL : https://hal.archives-ouvertes.fr/hal-02527545

S. Leteurtre, PELOD-2: an update of the PEdiatric Logistic Organ Dysfunction score, Crit Care Med, vol.41, issue.7, pp.1761-73, 2013.

J. M. Lachin, Introduction to sample size determination and power analysis for clinical trials, Controlled Clin Trials, vol.2, pp.93-113, 1981.

P. C. O'brien and T. R. Fleming, A multiple testing procedure for clinical trials, Biometrics, vol.35, issue.3, pp.549-56, 1979.

J. Robins, N. Breslow, and S. Greenland, Estimators of the Mantel-Haenszel variance consistent in both sparse data and large-strata limiting models, Biometrics, vol.42, issue.2, pp.311-334, 1986.

M. M. Pollack, K. M. Patel, and U. E. Ruttimann, PRISM III: an updated pediatric risk of mortality score, Crit Care Med, vol.24, issue.5, pp.743-52, 1996.

J. Lacroix, Transfusion strategies for patients in pediatric intensive care units, N Engl J Med, vol.356, issue.16, pp.1609-1628, 2007.

R. Wang, Statistics in medicine-reporting of subgroup analyses in clinical trials, N Engl J Med, vol.357, issue.21, pp.2189-94, 2007.

K. W. Chung, Declining blood collection and utilization in the United States, Transfusion, vol.56, pp.2184-92, 2016.

C. D. Josephson, One size will never fit all: the future of research in pediatric transfusion medicine, Pediatr Res, vol.76, issue.5, pp.425-456, 2014.

A. Dhabangi, Effect of transfusion of red blood cells with longer vs shorter storage duration on elevated blood lactate levels in children with severe anemia: the TOTAL randomized clinical trial, JAMA, vol.314, issue.23, pp.2514-2537, 2015.