Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Release-killing properties of a textile modified by a layer-by-layer coating based on two oppositely charged cyclodextrin polyelectrolytes

Abstract : Infections represent a major medical concern and have severe impact on the public health economy. Antimicrobial coatings represent one major solution and are the subject of many investigations in academic and industrial research. Polyelectrolyte multilayers (PEMs) consist in the step-by-step deposition of polyanions and polycations films on surfaces. The wide range of disposable polyelectrolytes makes this approach among the most versatile methods as it allows to design surfaces that prevent bacterial adhesion, and kill bacteria by contact or by releasing antibacterial agents. The present work focused on the release-killing effect of an active PEM coating of a polyethylene terephthalate (PET) textile support. This activity was obtained thanks to the PEM film build up using cationic and anionic polyelectrolytes both based on cyclodextrins (PCD- and PCD+) that provided a reservoir property and prolonged release of triclosan (TCS). To this effect, a PET non-woven preliminarily modified with carboxylate groups by applying a thermofixation process was then treated by dip-coating, alternating soaking cycles in cationic PCD+ and in anionic PCD- solutions. Samples coated with such PEM film were then loaded with TCS whose release was assessed in dynamic mode in a phosphate buffered saline solution (PBS) at 37 °C. In parallel, TCS/PCD+ and TCS/PCD- interactions were investigated by Nuclear Magnetic Resonance (NMR) and phase solubility study, and the biocide activity was assessed against S. aureus and E. coli. Finally, the present study has demonstrated that our PCD+/PCD- PEM system presented release-killing properties that supplement the contact-killing effect of this system that was reported in a previous paper.
Type de document :
Article dans une revue
Liste complète des métadonnées
Contributeur : Lilloa Université de Lille Connectez-vous pour contacter le contributeur
Soumis le : mardi 1 septembre 2020 - 11:20:43
Dernière modification le : mercredi 27 octobre 2021 - 05:49:51

Lien texte intégral





Jatupol Junthip, Nicolas Tabary, Mickael Maton, Safa Ouerghemmi, Jean-Noel Staelens, et al.. Release-killing properties of a textile modified by a layer-by-layer coating based on two oppositely charged cyclodextrin polyelectrolytes. International Journal of Pharmaceutics, Elsevier, 2020, International Journal of Pharmaceutics, 587, pp.119730. ⟨10.1016/j.ijpharm.2020.119730⟩. ⟨hal-02926939⟩



Consultations de la notice