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Reward anticipation in schizophrenia: A coordinate-based meta-analysis

Abstract : Reward processing impairments have been linked with positive and negative symptoms of schizophrenia. Here, we performed a coordinate-based meta-analysis that combined eleven BOLD-fMRI studies comparing reward anticipation signals between schizophrenia patients and healthy controls. We observed a reduced difference in activation in schizophrenia patients within a frontal-striatal network. Meta-regressions revealed that this functional signature was linked to the severity of psychotic symptoms and persisted even after controlling for the dose of antipsychotic medications.
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https://hal.univ-lille.fr/hal-02974702
Contributeur : Lilloa Université de Lille <>
Soumis le : vendredi 13 novembre 2020 - 15:51:33
Dernière modification le : jeudi 26 novembre 2020 - 03:21:38

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Arnaud Leroy, Ali Amad, Fabien d'Hondt, D. Pins, Nematollah Jaafari, et al.. Reward anticipation in schizophrenia: A coordinate-based meta-analysis. Schizophrenia Research, 2020, Schizophrenia Research, 218, pp.2-6. ⟨10.1016/j.schres.2019.12.041⟩. ⟨hal-02974702v2⟩

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