Definition of the Anti-inflammatory Oligosaccharides Derived From the Galactosaminogalactan (GAG) From Aspergillus fumigatus - Université de Lille Accéder directement au contenu
Article Dans Une Revue Frontiers in Cellular and Infection Microbiology Année : 2019

Definition of the Anti-inflammatory Oligosaccharides Derived From the Galactosaminogalactan (GAG) From Aspergillus fumigatus

Résumé

Galactosaminogalactan (GAG) is an insoluble aminosugar polymer produced byAspergillus fumigatusand has anti-inflammatory properties. Here, the minimumglycosidic sequences required for the induction of IL-1Ra by peripheral bloodmononuclear cells (PBMCs) was investigated. Using chemical degradation of native GAGto isolate soluble oligomers, we have found that the de-N-acetylation of galactosamineresidues and the size of oligomer are critical for thein vitroimmune response. A minimaloligomer size of 20 galactosamine residues is required for the anti-inflammatory responsebut the presence of galactose residues is not necessary. In aDextran sulfate inducedcolitis mouse model, a fraction of de-N-acetylated oligomers of 13
Fichier principal
Vignette du fichier
P19.09 article oligo aspergillus.pdf (961.81 Ko) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03044465 , version 1 (07-12-2020)

Licence

Identifiants

Citer

Markus Gressler, Christoph Heddergott, Inés C. N'Go, Giorgia Renga, Vasilis Oikonomou, et al.. Definition of the Anti-inflammatory Oligosaccharides Derived From the Galactosaminogalactan (GAG) From Aspergillus fumigatus. Frontiers in Cellular and Infection Microbiology, 2019, Frontiers in Cellular and Infection Microbiology, 9, pp.365. ⟨10.3389/fcimb.2019.00365⟩. ⟨hal-03044465⟩
38 Consultations
44 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More