Definition of the Anti-inflammatory Oligosaccharides Derived From the Galactosaminogalactan (GAG) From Aspergillus fumigatus
Résumé
Galactosaminogalactan (GAG) is an insoluble aminosugar polymer produced byAspergillus fumigatusand has anti-inflammatory properties. Here, the minimumglycosidic sequences required for the induction of IL-1Ra by peripheral bloodmononuclear cells (PBMCs) was investigated. Using chemical degradation of native GAGto isolate soluble oligomers, we have found that the de-N-acetylation of galactosamineresidues and the size of oligomer are critical for thein vitroimmune response. A minimaloligomer size of 20 galactosamine residues is required for the anti-inflammatory responsebut the presence of galactose residues is not necessary. In aDextran sulfate inducedcolitis mouse model, a fraction of de-N-acetylated oligomers of 13
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Soumis le : lundi 7 décembre 2020-17:55:28
Dernière modification le : mercredi 24 janvier 2024-09:54:18
Archivage à long terme le : lundi 8 mars 2021-19:43:00
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- HAL Id : hal-03044465 , version 1
- DOI : 10.3389/fcimb.2019.00365
- PUBMED : 31781511
- PUBMEDCENTRAL : PMC6851199
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Markus Gressler, Christoph Heddergott, Inés C. N'Go, Giorgia Renga, Vasilis Oikonomou, et al.. Definition of the Anti-inflammatory Oligosaccharides Derived From the Galactosaminogalactan (GAG) From Aspergillus fumigatus. Frontiers in Cellular and Infection Microbiology, 2019, Frontiers in Cellular and Infection Microbiology, 9, pp.365. ⟨10.3389/fcimb.2019.00365⟩. ⟨hal-03044465⟩
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