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Article Dans Une Revue Biological Psychiatry Année : 1996

Depression as a dynamical disease


Mathematical models are helpful in the understanding of diseases through the use of dynamical indicators. A previous study has shown that brain activity can be characterized by a decrease of dynamical complexity in depressive subjects. The present paper confirms and extends these conclusions through the use of recent methodological advances: first episode and recurrent patients strongly differ in their dynamical response to therapeutic interventions. These results emphasize the need for clinical follow-ups to avoid recurrence and the necessity of specific therapeutic intervention in the case of recurrent patients.

Dates et versions

hal-03105561 , version 1 (11-01-2021)



Laurent Pezard, Jean-Louis Nandrino, Bernard Renault, Farid El Massioui, Jean-François Allilaire, et al.. Depression as a dynamical disease. Biological Psychiatry, 1996, Biological Psychiatry, 39 (12), pp.991-999. ⟨10.1016/0006-3223(95)00307-x⟩. ⟨hal-03105561⟩
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