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A 980nm driven photothermal ablation of virulent and antibiotic resistant Gram-positive and Gram-negative bacteria strains using Prussian blue nanoparticles
Abstract : A 980nm laser-driven antimicrobial photothermal therapy using poly(vinylpyrrolidone) -coated Prussian Blue nanoparticles (PVP/PB NPs) is demonstrated. This approach allows an efficient eradication of a virulent strain of Gram-negative Escherichia coli (E. coli) associated with urinary tract infection as well as for the ablation of antibiotic resistant pathogens such as methicillin resistant Staphylococcus aureus (MRSA) and extended spectrum β-lactamase (ESBL) E. coli. Interestingly the 980nm irradiation exhibits minimal effect on mammalian cells up to a PVP/PB NPs concentration of 50μgmL(-1), while at this concentration bacteria are completely eradicated. This feature is certainly very promising for the selective targeting of bacteria over mammalian cells.
Keywords :
Nanoparticles
Photochemical Processes
Drug Resistance
Temperature
Gram-Negative Bacteria
Gram negative
Gram-Positive Bacteria
Near infrared
Microbial Sensitivity Tests
Particle Size
Microbial
Ferrocyanides
Anti-Bacterial Agents
Surface Properties
Bacteria
Prussian blue
Gram positive
Photothermal
https://hal.univ-lille.fr/hal-03153645
Contributeur : Lilloa Université de Lille Connectez-vous pour contacter le contributeur
Soumis le : vendredi 26 février 2021 - 15:39:08
Dernière modification le : mardi 19 octobre 2021 - 18:11:43
Contributeur : Lilloa Université de Lille Connectez-vous pour contacter le contributeur
Soumis le : vendredi 26 février 2021 - 15:39:08
Dernière modification le : mardi 19 octobre 2021 - 18:11:43