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Article Dans Une Revue BBA - Biochimica et Biophysica Acta Année : 2014

The structure of the CD3ζζ transmembrane dimer in lipid bilayers

Résumé

Virtually every aspect of the human adaptive immune response is controlled by T cells. The T cell receptor (TCR) complex is responsible for the recognition of foreign peptide sequences, forming the initial step in the elimination of germ-infected cells. The recognition leads to an extracellular conformational change that is transmitted intracellularly through the Cluster of Differentiation 3 (CD3) subunits of the TCR-CD3 complex. Here we address the interplay between the disulfide-linked CD3ζζ dimer, an essential signaling component of the TCR-CD3 complex, and its lipidic environment. The disulfide bond formation requires the absolute presence of a nearby conserved aspartic acid, a fact that has mystified the scientific community. We use atomistic simulation methods to demonstrate that the conserved aspartic acid pair of the CD3ζζ dimer leads to a deformation of the membrane. This deformation changes the local environment of the cysteines and promotes disulfide bond formation. We also investigate the role of a conserved Tyr, highlighting its possible role in the interaction with other transmembrane components of the TCR-CD3 complex.

Dates et versions

hal-03171753 , version 1 (17-03-2021)

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Satyan Sharma, Marc Lensink, André H. Juffer. The structure of the CD3ζζ transmembrane dimer in lipid bilayers. BBA - Biochimica et Biophysica Acta, 2014, Biochimica et biophysica acta, 1838 (3), pp.739-746. ⟨10.1016/j.bbamem.2013.12.001⟩. ⟨hal-03171753⟩

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