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Article dans une revue

Plasmonic photothermal destruction of uropathogenic E. coli with reduced graphene oxide and core/shell nanocomposites of gold nanorods/reduced graphene oxide

Abstract : The development of non-antibiotic based treatments against bacterial infections by Gram-negative uropathogenic E. coli is a complex task. New strategies to treat such infections are thus urgently needed. This report illustrates the development of pegylated reduced graphene oxide nanoparticles (rGO-PEG) and gold nanorods (Au NRs) coated with rGO-PEG (rGO-PEG-Au NRs) for the selective killing of uropathogenic E. coli UTI89. We took advantage of the excellent light absorption properties of rGO-PEG and Au NR particles in the near-infrared (NIR) region to photothermally kill Gram-negative pathogens up to 99% in 10 min by illumination of solutions containing the bacteria. The rGO-PEG-Au NRs demonstrated better photothermal efficiency towards E. coli than rGO-PEG. Targeted killing of E. coli UTI89 could be achieved with rGO-PEG-Au NRs functionalized with multimeric heptyl α-D-mannoside probes. This currently offers a unique biocompatible method for the ablation of pathogens with the opening of probably a new possibility for clinical treatments of patients with urinary infections.
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https://hal.univ-lille.fr/hal-03205552
Contributeur : Lilloa Université de Lille <>
Soumis le : jeudi 22 avril 2021 - 13:41:26
Dernière modification le : vendredi 23 avril 2021 - 03:38:15

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Kostiantyn Turcheniuk, Charles-Henri Hage, Jolanda Spadavecchia, Aritz Yanguas Serrano, Iban Larroulet, et al.. Plasmonic photothermal destruction of uropathogenic E. coli with reduced graphene oxide and core/shell nanocomposites of gold nanorods/reduced graphene oxide. Journal of materials chemistry‎ B, Royal Society of Chemistry, 2015, Journal of Materials Chemistry B, 3 (3), pp.375-386. ⟨10.1039/C4TB01760A⟩. ⟨hal-03205552⟩

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