One-Pot Synthesis of 2,5-Disubstituted Furans through In Situ Formation of Allenes and Enolization Cascade - Université de Lille Accéder directement au contenu
Article Dans Une Revue European Journal of Organic Chemistry Année : 2019

One-Pot Synthesis of 2,5-Disubstituted Furans through In Situ Formation of Allenes and Enolization Cascade

Résumé

A one-pot synthesis of 2,5-disubstituted furans from γ-ketoacids is reported. In situ formation of allenoates by action of chloroformate on carboxylic acid following by enolization of ketone affords to furan derivatives by cyclization. The reaction was extended on a wide scope of ketoacids and phosphonium salts. This methodology was applied on levulinic acid and derivatives, one of the biosourced platform chemicals.

Domaines

Chimie organique
Fichier principal
Vignette du fichier
2019 - Bernhard Eur. J. Org. Chem. 2019.pdf (1.58 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03263313 , version 1 (17-06-2021)

Identifiants

Citer

Yann Bernhard, Joachim Gilbert, Till Bousquet, Audrey Favrelle-Huret, Philippe Zinck, et al.. One-Pot Synthesis of 2,5-Disubstituted Furans through In Situ Formation of Allenes and Enolization Cascade. European Journal of Organic Chemistry, 2019, European Journal of Organic Chemistry, 2019 (48), pp.7870-7873. ⟨10.1002/ejoc.201901669⟩. ⟨hal-03263313⟩
37 Consultations
110 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More