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Poly-cyclodextrin functionalized porous bioceramics for local chemotherapy and anticancer bone reconstruction

Abstract : The progress in bone cancer surgery and multimodal treatment concept achieve only modest improvement in the overall survival, due to failure in clearing out residual cancer cells at the surgical margin and extreme side-effects of adjuvant postoperative treatments. Our study aims to propose a new method based on cyclodextrin polymer (polyCD) functionalized hydroxyapatite (HA) for achieving a high local drug concentration with a sustained release profile and a better control of residual malignant cells via local drug delivery and promotion of the reconstruction of bone defects. PolyCD, a versatile carrier for therapeutic molecules, can be incorporated into HA (bone regeneration scaffold) through thermal treatment. The parameters of polyCD treatment on the macroporous HA (porosity 65%) were characterized via thermogravimetric analysis. Good cytocompatibility of polyCD functionalized bioceramics was demonstrated on osteoblast cells by cell vitality assay. An antibiotic (gentamicin) and an anticancer agent (cisplatin) were respectively loaded on polyCD functionalized bioceramics for drug release test. The results show that polyCD functionalization leads to significantly improved drug loading quantity (30% more concerning gentamicin and twice more for cisplatin) and drug release duration (7 days longer concerning gentamicin and 3 days longer for cisplatin).
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Soumis le : mercredi 29 septembre 2021 - 12:30:14
Dernière modification le : mercredi 23 mars 2022 - 15:51:27

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Feng Chai, Mohammed Abdelkarim, Thomas Laurent, Nicolas Tabary, Stephanie Degoutin, et al.. Poly-cyclodextrin functionalized porous bioceramics for local chemotherapy and anticancer bone reconstruction. Journal of Biomedical Materials Research, John Wiley & Sons, 2014, Journal of Biomedical Materials Research Part B. Applied Biomaterials, 102 (6), pp.1130-1139. ⟨10.1002/jbm.b.33094⟩. ⟨hal-03358369⟩



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