New NSAIDs-NO hybrid molecules with antiproliferative properties on human prostatic cancer cell lines - Université de Lille
Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2008

New NSAIDs-NO hybrid molecules with antiproliferative properties on human prostatic cancer cell lines

Résumé

The design of profen hybrids containing a NO donor moiety connected to an aliphatic spacer led to compounds with a similar cyclooxygenase inhibition compared to their parent profen and with significant antiproliferative activities on PC3 cells. However, inhibition of COX-2 pathway alone did not seem sufficient to inhibit cancer cell proliferation, and NO-release in a time-dependent manner strongly contributes to this activity.

Dates et versions

hal-03373117 , version 1 (11-10-2021)

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Citer

Nicolas Bézière, Laurence Goossens, Jean Pommery, Herve Vezin, Nadia Touati, et al.. New NSAIDs-NO hybrid molecules with antiproliferative properties on human prostatic cancer cell lines. Bioorganic and Medicinal Chemistry Letters, 2008, Bioorganic & Medicinal Chemistry Letters, 18 (16), pp.4655-4657. ⟨10.1016/j.bmcl.2008.07.018⟩. ⟨hal-03373117⟩

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