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Article dans une revue

Dressings Loaded with Cyclodextrin-Hamamelitannin Complexes Increase Staphylococcus aureus Susceptibility Toward Antibiotics Both in Single as well as in Mixed Biofilm Communities

Abstract : Bacteria reside within biofilms at the infection site, making them extremely difficult to eradicate with conventional wound care products. Bacteria use quorum sensing (QS) systems to regulate biofilm formation, and QS inhibitors (QSIs) have been proposed as promising antibiofilm agents. Despite this, few antimicrobial therapies that interfere with QS exist. Nontoxic hydroxypropyl-β-cyclodextrin-functionalized cellulose gauzes releasing a burst of the antibiotic vancomycin and the QSI hamamelitannin are developed, followed by a sustained release of both. The gauzes affect QS and biofilm formation of Pseudomonas aeruginosa and Staphylococcus aureus in an in vitro model of chronic wound infection and can be considered as candidates to be used to prevent wound infection as well as treat infected wounds
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https://hal.univ-lille.fr/hal-03481113
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Soumis le : mercredi 15 décembre 2021 - 10:29:17
Dernière modification le : mercredi 23 mars 2022 - 15:51:10

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Gilles Brackman, Maria-Jose Garcia Fernandez, Joke Lenoir, Laurens de Meyer, Jean-Paul Remon, et al.. Dressings Loaded with Cyclodextrin-Hamamelitannin Complexes Increase Staphylococcus aureus Susceptibility Toward Antibiotics Both in Single as well as in Mixed Biofilm Communities. Macromolecular Bioscience, Wiley-VCH Verlag, 2016, Macromolecular Bioscience, 16, pp.859-869. ⟨10.1002/mabi.201500437⟩. ⟨hal-03481113⟩

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