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Article Dans Une Revue Frontiers in Immunology Année : 2021

Clinical relevance of serum kyn/trp ratio and basal and ifnγ-upregulated ido1 expression in peripheral monocytes in early stage melanoma

Résumé

Immune escape is an early phenomenon in cancer development/progression. Indoleamine 2,3-dioxygenase 1 (IDO1) is a normal endogenous mechanism of acquired peripheral immune tolerance and may therefore be tumor-promoting. This study investigated the clinical relevance of IDO1 expression by immune cells in the lymph nodes and blood and of the serum kynurenine/tryptophan (Kyn/Trp) ratio in 65 systemic treatment naïve stage I-III melanoma patients. Blood samples were collected within the first year of diagnosis. Patients had a median follow-up of 61 months. High basal IDO1 expression in peripheral monocytes and low IFNγ-induced IDO1 upregulation correlated with worse outcome independent from disease stage. Interestingly studied factors were not interrelated. During follow-up, the risk of relapse was 9% (2/22) in the subgroup with high IFNγ-induced IDO1 upregulation in monocytes. In contrast, if IDO1 upregulation was low, relapse occurred in 30% (3/10) of patients with low basal IDO1 expression in monocytes and in 61.5% (8/13) in the subgroup with high basal IDO1 expression in monocytes (Log-Rank test, p=0.008). This study reveals some immune features in the blood of early stage melanoma that may be of relevance for disease outcome. These may offer a target for sub-stratification and early intervention.
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Dates et versions

hal-03676907 , version 1 (24-05-2022)

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Annabel Meireson, Liesbeth Ferdinande, Marc Haspeslagh, Benjamin Hennart, Delphine Allorge, et al.. Clinical relevance of serum kyn/trp ratio and basal and ifnγ-upregulated ido1 expression in peripheral monocytes in early stage melanoma. Frontiers in Immunology, 2021, 12, pp.736498. ⟨10.3389/fimmu.2021.736498⟩. ⟨hal-03676907⟩

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