Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Is copd associated with increased risk for microaspiration in intubated critically ill patients ?

Abstract : BACKGROUND: Although COPD patients are at higher risk for aspiration when breathing spontaneously, no information is available on the risk for microaspiration in invasively ventilated COPD patients. The aim of our study was to determine the relationship between COPD and abundant microaspiration in intubated critically ill patients. METHODS: This was a retrospective analysis of prospectively collected data, provided by 3 randomized controlled trials on microaspiration in critically ill patients receiving invasive mechanical ventilation for more than 48 h. Abundant microaspiration was defined as the presence of pepsin and or alpha-amylase at significant levels in tracheal aspirates. In all study patients, pepsin and alpha-amylase were quantitatively measured in all tracheal aspirates collected during a 48-h period. COPD was defined using spirometry criteria. RESULTS: Among the 515 included patients, 70 (14%) had proven COPD. Pepsin and alpha-amylase were quantitatively measured in 3873 and 3764 tracheal aspirates, respectively. No significant difference was found in abundant microaspiration rate between COPD and non-COPD patients (62 of 70 patients (89%) vs 366 of 445 (82%) patients, p = 0.25). Similarly, no significant difference was found in abundant microaspiration of gastric contents (53% vs 45%, p = 0.28), oropharyngeal secretions (71% vs 71%, p = 0.99), or VAP (19% vs 22%, p = 0.65) rates between the two groups. No significant difference was found between COPD and non-COPD patients in duration of mechanical ventilation, ICU length of stay, or ICU mortality. CONCLUSIONS: Our results suggest that COPD is not associated with increased risk for abundant microaspiration in intubated critically ill patients.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal.univ-lille.fr/hal-03678143
Contributeur : LillOA Université de Lille Connectez-vous pour contacter le contributeur
Soumis le : mercredi 25 mai 2022 - 11:15:04
Dernière modification le : mercredi 1 juin 2022 - 11:28:14

Fichier

Degroote et al..pdf
Fichiers éditeurs autorisés sur une archive ouverte

Licence


Distributed under a Creative Commons Paternité 4.0 International License

Identifiants

Citation

Thecle Degroote, Emmanuelle Jaillette, Jean Reignier, Farid Zerimech, Christophe Girault, et al.. Is copd associated with increased risk for microaspiration in intubated critically ill patients ?. Annals of Intensive Care, SpringerOpen, 2021, Annals of Intensive Care, 11, pp.7. ⟨10.1186/s13613-020-00794-1⟩. ⟨hal-03678143⟩

Partager

Métriques

Consultations de la notice

0

Téléchargements de fichiers

0