WHEN RESIDUAL WATER INFLUENCES THE COCRYSTALLIZATION OUTPUT: THE CARBAMAZEPINE AND TARTARIC ACID CASE - Université de Lille Accéder directement au contenu
Communication Dans Un Congrès Année : 2021

WHEN RESIDUAL WATER INFLUENCES THE COCRYSTALLIZATION OUTPUT: THE CARBAMAZEPINE AND TARTARIC ACID CASE

Résumé

The design of poorly water-soluble pharmaceutical molecules using cocrystallization has drawnincreasing interest as these new materials can be used in order to improve their dissolution rate, aqueous solubility, bioavailability and/or hygroscopicity. Different synthesis techniques can be used in order to obtain cocrystals such as crystallization from solution, neat and liquid-assisted grinding (LAG), among many others.In this work, the impact of residual water in the final cocrystallization product has been investigated by using two different synthesis techniques, solution evaporation and liquid assisted grinding. For this purpose, previously published systems were studied: carbamazepine with L-tartaric acid and carbamazepine with DL-tartaric acid. From these systems, two different cocrystals were obtained and characterized by using their thermal and structural behaviour. On one hand, the crystalline structure resolution of one of the cocrystals shows the obtention of an ordered system with an exact molar ratio. On the other hand, a known cocrystal, describedas a coformer channel-filled structure with an unknown molar ratio, was thoroughly investigated to determine the molar ratio.During this study, the influence (or lack of) of residual water on these systems was shown to be dependent on the obtained cocrystal as well as the chosen synthesis method and to have a great impact on the cocrystallization output.
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Dates et versions

hal-03969851 , version 1 (02-02-2023)

Identifiants

  • HAL Id : hal-03969851 , version 1

Citer

Luisa-Viviane Roca Paixao, Florence Danede, Natália T. Correia, Frédéric Affouard. WHEN RESIDUAL WATER INFLUENCES THE COCRYSTALLIZATION OUTPUT: THE CARBAMAZEPINE AND TARTARIC ACID CASE. Journées SolvATE 2021, Dec 2021, Lille, France. ⟨hal-03969851⟩
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