In Vitro and In Vivo Evaluation of a pH-, Microbiota- and Time-Based Oral Delivery Platform for Colonic Release - Université de Lille Accéder directement au contenu
Article Dans Une Revue European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V Année : 2022

In Vitro and In Vivo Evaluation of a pH-, Microbiota- and Time-Based Oral Delivery Platform for Colonic Release

Résumé

Several formulation strategies have been proposed for oral colon delivery, particularly for the therapy of inflammatory bowel disease (IBD). However, targeting the large intestine remains a challenging goal. The aim of this study was to develop and evaluate a novel type of drug delivery system, which is based on multiple drug release triggers for reliable performance. The system consists of: (i) a drug core, (ii) an inner swellable low-viscosity hydroxypropyl methylcellulose (HPMC) layer, and (iii) an outer film coating based on a Eudragit® S:high-methoxyl (HM) pectin (7:3 w/w) blend, optionally containing chitosan. Convex immediate release tablets (2 or 4 mm in diameter) containing paracetamol or 5-aminosalicylic acid (5-ASA) were coated in a fluid bed. The double-coated tablets exhibited pulsatile release profiles when changing the release medium from 0.1 N HCl to phosphate buffer pH 7.4. Also, drug release was faster in simulated colonic fluid (SCF) in the presence of fecal bacteria from IBD patients compared to control culture medium from tablets with outer Eudragit® S: HM pectin: chitosan coatings. The latter systems showed promising results in the control of the progression of colitis and alteration of the microbiota in a preliminary rat study.
Fichier principal
Vignette du fichier
Moutaharrik+S.+et+al%2C+EJPB+2023+PRE-PRINT.pdf (521.3 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04013724 , version 1 (19-03-2024)

Identifiants

Citer

S. Moutaharrik, A. Maroni, Christel Neut, Caroline Dubuquoy, Laurent Dubuquoy, et al.. In Vitro and In Vivo Evaluation of a pH-, Microbiota- and Time-Based Oral Delivery Platform for Colonic Release. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V, 2022, Eur J Pharm Biopharm, 183, pp.13-23. ⟨10.1016/j.ejpb.2022.12.013⟩. ⟨hal-04013724⟩

Collections

UNIV-LILLE
15 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More