Sensitivity of human meningioma cells to the cyclin-dependent kinase inhibitor, tg02 - Université de Lille Accéder directement au contenu
Article Dans Une Revue Translational Oncology Année : 2020

Sensitivity of human meningioma cells to the cyclin-dependent kinase inhibitor, tg02

Résumé

Standards of care for meningioma include surgical resection and radiotherapy whereas pharmacotherapy plays almost no role in this disease. We generated primary cultures from surgically removed meningiomas to explore the activity of a novel cyclin-dependent kinase inhibitor, TG02, in meningioma cell cultures. Tumor and cell cultures were characterized by mutation profiling and DNA methylation profiling. DNA methylation data were used to allot each sample to one out of six previously established meningioma methylation classes: benign (ben)-1, 2, 3, intermediate (int)-A, B, and malignant (mal). Four tumors assigned to the methylation class ben-2 showed the same class in culture whereas cultures from five non-ben-2 tumors showed a more malignant class in four patients. Cell cultures were uniformly sensitive to TG02 in the nanomolar range. Assignment of the cell cultures to a more malignant methylation class appeared to be more closely associated with TG02 sensitivity than assignment to a higher WHO grade of the primary tumors. Primary cell cultures from meningioma facilitate the investigation of the anti-meningioma activity of novel agents. TG02, an orally available cyclin-dependent kinase (CDK) inhibitor, warrants further exploration.
Fichier principal
Vignette du fichier
2020-09-08-1-s2.0-S1936523320303442-main.pdf (636.12 Ko) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04017434 , version 1 (07-03-2023)

Licence

Identifiants

Citer

Caroline von Achenbach, Emilie Le Rhun, Felix Sahm, Sophie S. Wang, Philipp Sievers, et al.. Sensitivity of human meningioma cells to the cyclin-dependent kinase inhibitor, tg02. Translational Oncology, 2020, Translational Oncology, 13 (12), pp.100852. ⟨10.1016/j.tranon.2020.100852⟩. ⟨hal-04017434⟩

Collections

UNIV-LILLE
6 Consultations
3 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More