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Article Dans Une Revue Annals of Surgical Oncology Année : 2020

Diagnostic accuracy of nipple aspirate fluid cytology in asymptomatic patients: a meta-analysis and systematic review of the literature

Natasha Jiwa
  • Fonction : Auteur
Rishikesh Gandhewar
  • Fonction : Auteur
Hemali Chauhan
  • Fonction : Auteur
Hutan Ashrafian
  • Fonction : Auteur
Swathica Kumar
  • Fonction : Auteur
Corrina Wright
  • Fonction : Auteur

Résumé

PURPOSE: To calculate the diagnostic accuracy of nipple aspirate fluid (NAF) cytology. BACKGROUND: Evaluation of NAF cytology in asymptomatic patients conceptually offers a non-invasive method for either screening for breast cancer or else predicting or stratifying future cancer risk. METHODS: Studies were identified by performing electronic searches up to August 2019. A meta-analysis was conducted to attain an overall pooled sensitivity and specificity of NAF for breast cancer detection. RESULTS: A search through 938 studies yielded a total of 19 studies. Overall, 9308 patients were examined, with cytology results from 10,147 breasts [age (years), mean +/- SD = 49.73 +/- 4.09 years]. Diagnostic accuracy meta-analysis of NAF revealed a pooled specificity of 0.97 (95% CI 0.97-0.98), and sensitivity of 0.64 (95% CI 0.62-0.66). CONCLUSIONS: The diagnostic accuracy of nipple smear cytology is limited by poor sensitivity. If nipple fluid assessment is to be used for diagnosis, then emerging technologies for fluid biomarker analysis must supersede the current diagnostic accuracy of NAF cytology.
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hal-04065835 , version 1 (12-04-2023)

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Natasha Jiwa, Rishikesh Gandhewar, Hemali Chauhan, Hutan Ashrafian, Swathica Kumar, et al.. Diagnostic accuracy of nipple aspirate fluid cytology in asymptomatic patients: a meta-analysis and systematic review of the literature. Annals of Surgical Oncology, 2020, Annals of Surgical Oncology, 28, ⟨10.1245/s10434-020-09313-9⟩. ⟨hal-04065835⟩

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