Impact of 4-month training on glycaemic excursions in daily life in adults living with type 1 diabetes
Résumé
Context and aim:
Physical acNvity is associated with decreased risk of cardiovascular disease, improved quality
of life and type 1 diabetes (T1D) management. In order to individualise recommendaNons
when implemented chronic exercise intervenNons, it seems important to beSer idenNfy the
glycaemic excursions (hypo and hyperglycaemia) occurring the days including supervised
exercise training sessions compared with the days without training. Whether these glycaemic
profiles are changing throughout several months of training and whether differences appear
according to the type of treatment (MDI or CSII) is also quesNonable.
Method:
FiWeen adults with T1D parNcipated to four-month combined (aerobic and strength) training
program. Glycaemic excursion (i.e. glycaemic variability MAGE and CV, Nme spent in hypo- (<54
and <70 mg.dL-1
), hyperglycaemia (>180 and >250 mg.dL-1
) and normoglycemia were
measured on both inacNvity and training days throughout the 4-month intervenNon.
Results:
Compared with training days, sedentary days led to a significant increase in Nme spent in
severe hypoglycaemia (<54mg.dL-1 : e : +1,66 p<0,001; <70mg.dL-1
: e : +1,39 p<0,001) and
hyperglycaemia (>250mg.dL-1 : e : +1.02 p<0.001). Concomitantly, MAGE was increased (e :
+1,087 p<0,05). Moreover, as the weeks of training passed, independently of being on an
‘inacNve’ or a ‘training’ day, MAGE (e : -1,06 p<0,01) and Nme spent in hyperglycaemia
(>180mg.dL-1 : e : -0,497, p<0,01 ; >250mg.dL-1 : e : -0,28 p<0,05) decreased and this more
markedly in people living with insulin pump (>180mg.dL-1 : e : -1,267 p <0,05; MAGE : e : -2,23
p<0,05 vs. MDI).
Conclusion:
These results mays suggest that individuals with T1D are more afraid of hypoglycaemic risk the
days with training vs. the inacNve days, thus controlling more their glycaemia and hence
anNcipaNng extreme glycaemic excursions.