Use of levodopa-carbidopa intestinal gel to treat patients with multiple system atrophy. - Université de Lille Accéder directement au contenu
Article Dans Une Revue Parkinsonism & Related Disorders Année : 2022

Use of levodopa-carbidopa intestinal gel to treat patients with multiple system atrophy.

Résumé

Background Levodopa-carbidopa intestinal gel (LCIG) is an effective treatment for late-stage Parkinson's disease (PD) but had not been evaluated in levodopa-responsive patients with the parkinsonian variant of multiple system atrophy (MSA-P) and motor fluctuations. We aimed to assess the safety of LCIG in MSA-P patients. Methods In a retrospective, single-center study, we analyzed clinical and treatment-related data for all patients with MSA-P or PD treated with LCIG between December 2004 and November 2017. Adverse events (AEs) were classified into three classes: AEs related to gastrointestinal effects or to the PEG-J procedure, AEs related to the device, and AEs related to the pharmacological effect of LCIG. Results 7 MSA-P and 63 PD patients had been treated with LCIG for a median [interquartile range] period of 31 [16;43] and 19 [8;45] months, respectively. There were no significant intergroup differences in safety. Enteral nutrition was introduced at the same time as LCIG treatment in 4 (57%) MSA-P patients. In the MSA-P and PD groups, LCIG was associated with a better Global Clinical Impression score and discontinuation of oral anti-parkinsonian drugs (in 43% and 27% of cases, respectively). Conclusions LCIG treatment is feasible in MSA-P patients with severe motor complications. The safety profile is similar to that seen in PD.

Dates et versions

hal-04151650 , version 1 (05-07-2023)

Identifiants

Citer

A. S. Blaise, Elodie Cuvelier, N. Carrière, David Devos, F. Moreau, et al.. Use of levodopa-carbidopa intestinal gel to treat patients with multiple system atrophy.. Parkinsonism & Related Disorders, 2022, Parkinsonism and Related Disorders, 100, pp.41-44. ⟨10.1016/j.parkreldis.2022.05.018⟩. ⟨hal-04151650⟩

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