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Article Dans Une Revue Pharmaceuticals Année : 2015

Opioid Facilitation of β-Adrenergic Blockade: A New Pharmacological Condition?

Résumé

Recently, propranolol was suggested to prevent hyperlactatemia in a child with hypovolemic shock through β-adrenergic blockade. Though it is a known inhibitor of glycolysis, propranolol, outside this observation, has never been reported to fully protect against lactate overproduction. On the other hand, literature evidence exists for a cross-talk between β-adrenergic receptors (protein targets of propranolol) and δ-opioid receptor. In this literature context, it is hypothesized here that anti-diarrheic racecadotril (a pro-drug of thiorphan, an inhibitor of enkephalinases), which, in the cited observation, was co-administered with propranolol, might have facilitated the β-blocker-driven inhibition of glycolysis and resulting lactate production. The opioid-facilitated β-adrenergic blockade would be essentially additivity or even synergism putatively existing between antagonism of β-adrenergic receptors and agonism of δ-opioid receptor in lowering cellular cAMP and dependent functions.
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hal-04239045 , version 1 (12-10-2023)

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Joseph Vamecq, K. Mention-Mulliez, F. Leclerc, Dries Dobbelaere. Opioid Facilitation of β-Adrenergic Blockade: A New Pharmacological Condition?. Pharmaceuticals, 2015, Pharmaceuticals, 8 (4), pp.664-674. ⟨10.3390/ph8040664⟩. ⟨hal-04239045⟩

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