The digital transition in our society raises the question of digital media use by children and adolescents and within parent- child relationships, especially for vulnerable families. Media use could be related to some negative developmental out- comes in children and adolescents, but it could also offer many opportunities for social bonding and for therapeutics. As a consequence, it seems important to explore individual and environmental features involved in children’s and adolescents’ media use, to examine association between me- dia use and socio-emotional development and to understand how media use could be involved in children’s and adolescents’ well-being. The symposium aims to present recent findings on the factors of vulnerability/protection in media use and the use of digital devices for therapeutic purposes. A first presentation addresses the question of the interruption of parent-toddlers’ interactions due to parents’ media use (technoference) and their relation to child socio-emotional behaviors (DATE project). A second presentation exposes findings on the relation between school- aged children’s media use and their effortful control, tempera- ment, problem behaviors (UNDERPIn project). A third communication presents a systemic review (PRISMA method) on social media use in intellectu- ally disabled persons and its implication for social development in intellectually disabled adolescent (ADIMES project). Finally, a fourth contribution fo- cuses on an online therapeutic platform designed to allow easy access to personalized, accessible, and validated prevention in order to promote emo- tional health in children and adolescents. The dis- cussion will address the question of guidelines and digital parenting in order to improve opportunities and decrease risks in media use.