Sustainable and selective Ni-catalyzed allylation of 2-oxindoles and 2-coumaranones in batch and flow chemistry - Université de Lille Accéder directement au contenu
Article Dans Une Revue Reaction Chemistry & Engineering Année : 2023

Sustainable and selective Ni-catalyzed allylation of 2-oxindoles and 2-coumaranones in batch and flow chemistry

Résumé

2-Oxindoles and 2-coumaranones could be selectively allylated in the presence of low cost catalysts based on nickel, leading selectively to different polysubstituted derivatives. Allyl alcohol was used as an allylating reagent and allowed the synthesis of compounds under neutral conditions with water produced as the sole by-product. Experiments have been performed in batch and in flow chemistry. The latter protocol in flow led to a very efficient and straightforward allylic alkylation of 2-oxindoles in only a few minutes with high chemoselectivities towards either the C,C-bisallylated product or the C,C,N-trisallylated one.

Domaines

Catalyse
Fichier principal
Vignette du fichier
Sustainable and selective Ni catalyzed allylation of 2 oxindoles and 2 coumaranones in batch and flow chemistry.pdf (898.23 Ko) Télécharger le fichier
Origine Publication financée par une institution
Licence

Dates et versions

hal-04273937 , version 1 (09-11-2023)

Licence

Identifiants

Citer

Bouchaib Mouhsine, Anthony Saint Pol, Abdallah Karim, Maël Penhoat, Clement Dumont, et al.. Sustainable and selective Ni-catalyzed allylation of 2-oxindoles and 2-coumaranones in batch and flow chemistry. Reaction Chemistry & Engineering, 2023, Reaction Chemistry & Engineering, 8, pp.2549-2556. ⟨10.1039/d3re00192j⟩. ⟨hal-04273937⟩
19 Consultations
20 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More