Limb apraxia is a complex disorder of skilled movement characterized by spatiotemporal errors in movement imitation and pantomime, difficulty selecting object-appropriate actions, and deficits in tool action knowledge. Despite its demonstrated relevance for our understanding of the cognitive neuroscience of skilled action, it has received relatively little study. Classical accounts of the disorder focused on a classification approach to apraxia’s numerous patterns of symptom dissociation and association, usually without accompanying neuroanatomic data; hindering scientific progress. Recent advances in approaches to lesion analysis and corroborating data from functional neuroimaging studies of neurotypical subjects have enabled a new understanding of a specialized praxis network in the left hemisphere. After brief discussion of traditional accounts, this chapter provides a review of our current neurocognitive understanding of this praxis system. In particular, three major clusters of behaviors reflecting damage to conceptual, spatio-temporal, and selection-based components of skilled action planning are discussed, attributable to posterior temporal, inferior parietal, and frontal network nodes and their interconnections. We conclude by offering suggestions for several future research directions that will benefit the study of apraxia, its rehabilitation, and our broad understanding of action imitation and tool use.