Purpose: Previous research conducted among caregivers of patients with cancer revealed a poor Quality of Life (QoL) and high levels of distress. In addition to the influence of patients’ clinical state, caregivers’ appraisals of patients’ difficulties should be considered as another predictor of poor caregiver health. This study aims to test the association between caregivers’ health (i.e., QoL, depression and anxiety) and their perception of patients’ difficulties. Methods: 199 caregivers of patients with cancer completed an online survey based on questionnaires measuring their QoL, depression and anxiety, as well as their perception of patients’ cognitive, emotional, functional, psychiatric and interpersonal difficulties. Results: It was found that the appraisal of patients’ impairments in all domains was mainly correlated with poor caregivers’ QoL . Furthermore, linear regression analyses showed that, after controlling for age, sex education level, professional activity and living with or without the patient, the appraisal of patients’ interpersonal abilities , psychiatric difficulties and living with the patient were the main predictors of caregivers’ QoL. Conclusion: This study highlights the importance of better understanding the role of patients’ social and psychiatric difficulties when examining caregivers’ health. This indicates the importance of providing support and offering information to caregivers to alert them to the role of patients’ social and psychiatric difficulties on their own health. Future studies should better understand how these difficulties are associated with caregivers’ perception of identity/sociability alterations in patients and how caregivers cope with these changes.