Extracorporeal photopheresis for GVHD prophylaxis after reduced intensity conditioning allogeneic hematopoietic stem cell transplantation: a prospective multicenter phase 2 study - Université de Lille Accéder directement au contenu
Article Dans Une Revue Leukemia & lymphoma Année : 2018

Extracorporeal photopheresis for GVHD prophylaxis after reduced intensity conditioning allogeneic hematopoietic stem cell transplantation: a prospective multicenter phase 2 study

Mauricette Michallet
  • Fonction : Auteur
Mohamad Sobh
  • Fonction : Auteur
Frederic Garban
  • Fonction : Auteur
Claude-Eric Bulabois
  • Fonction : Auteur
Valerie Coiteux
  • Fonction : Auteur
Remy Dulery
  • Fonction : Auteur
Pierre-Simon Rohrlich
  • Fonction : Auteur
Faezeh Legrand
  • Fonction : Auteur
Laurence Clement
  • Fonction : Auteur
Aline Praire
  • Fonction : Auteur
Marie Detrait
  • Fonction : Auteur
Fiorenza Barraco
  • Fonction : Auteur
Emmanuel Nicolini Franck
  • Fonction : Auteur
Olivier Hequet
  • Fonction : Auteur

Résumé

We performed a prospective multicenter phase 2 study to evaluate the safety and efficacy of prophylactic Extracorporeal Photopheresis (ECP) in adult patients with hematological malignancies early after RIC allo-HSCT on day 21 twice per week during the first two weeks and then once per week for the next four weeks for a total of eight ECP courses. A total of 20 patients were included; 10 were males, median age was 60 years. All patients engrafted, 17 (85%) received the total eight ECP courses. There were no adverse effects related to ECP. Seven patients developed acute graft-versus-host disease (GVHD), with 15% grade ≥ II cumulative incidence at day 100. The cumulative incidence of chronic GVHD at 2 years was 22%. The 2 years probability of overall survival (OS) and progression-free survival (PFS) were 84 and 74%, respectively. This study shows encouraging results with low acute and chronic GVHD incidence and no interference with graft-versus-leukemia (GVL) effect.
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Dates et versions

hal-04315330 , version 1 (30-11-2023)

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Citer

Mauricette Michallet, Mohamad Sobh, Frederic Garban, Claude-Eric Bulabois, Ibrahim Yakoub-Agha, et al.. Extracorporeal photopheresis for GVHD prophylaxis after reduced intensity conditioning allogeneic hematopoietic stem cell transplantation: a prospective multicenter phase 2 study. Leukemia & lymphoma, 2018, Leukemia & lymphoma, 59, pp.372-380. ⟨10.1080/10428194.2017.1334120⟩. ⟨hal-04315330⟩

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