Cytotect®CP as salvage therapy in patients with CMV infection following allogeneic hematopoietic cell transplantation: a multicenter retrospective study. - Université de Lille Accéder directement au contenu
Article Dans Une Revue Bone Marrow Transplantation Année : 2018

Cytotect®CP as salvage therapy in patients with CMV infection following allogeneic hematopoietic cell transplantation: a multicenter retrospective study.

Tamim Alsuliman
  • Fonction : Auteur
Caroline Kitel
  • Fonction : Auteur
Thierry Guillaume
  • Fonction : Auteur
Fabrice Larosa
  • Fonction : Auteur
Jerome Cornillon
  • Fonction : Auteur
Helene Labussiere-Wallet
  • Fonction : Auteur
Clemence Mediavilla
  • Fonction : Auteur
Stephanie Belaiche
  • Fonction : Auteur
Jeremy Delage
  • Fonction : Auteur

Résumé

Cytomegalovirus is one of the main contributing factors to high mortality rates in patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT). The main factors of treatment failure are both drug resistance and intolerance. In some cases, Cytotect(R)CP CMV-hyperimmune globulin is used as salvage therapy. This study aims to investigate the safety and efficacy of Cytotect(R)CP as a salvage therapy in patients with CMV infection after allo-HCT. Twenty-three consecutive patients received Cytotect(R)CP for CMV infection after prior CMV therapy. At the time of Cytotect(R)CP introduction, 17 patients (74%) had developed acute GVHD and 15 patients (64%) were receiving steroid treatment; Cytotect(R)CP was used as monotherapy (n = 7) and in combination (n = 16). Overall, response was observed in 18 patients (78%) with a median time of 15 days (range: 3-51). Of the 18 responders, 4 experienced CMV reactivation, while 5 responders died within 100 days of beginning treatment. Of these 5 deaths, 4 were due to causes unrelated to CMV. Estimated 100-day OS from the introduction of Cytotect(R)CP was 69.6%. No statistically significant difference was observed in 100-day OS between responders and non-responders (73.7% vs 50.0%, p = 0.258). Cytotect(R)CP as salvage therapy is effective and well-tolerated. Given its safety profile, early treatment use should be considered.

Dates et versions

hal-04318037 , version 1 (01-12-2023)

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Citer

Tamim Alsuliman, Caroline Kitel, Remy Dulery, Thierry Guillaume, Fabrice Larosa, et al.. Cytotect®CP as salvage therapy in patients with CMV infection following allogeneic hematopoietic cell transplantation: a multicenter retrospective study.. Bone Marrow Transplantation, 2018, Bone Marrow Transplantation, 53, pp.1328-1335. ⟨10.1038/s41409-018-0166-9⟩. ⟨hal-04318037⟩
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