C-reactive protein and procalcitonin profile in ventilator-associated lower respiratory infections. - Université de Lille Accéder directement au contenu
Article Dans Une Revue Journal of Critical Care Année : 2018

C-reactive protein and procalcitonin profile in ventilator-associated lower respiratory infections.

Luis Coelho
  • Fonction : Auteur
Ligia Rabello
  • Fonction : Auteur
Jorge Salluh
  • Fonction : Auteur
Ignacio Martin-Loeches
  • Fonction : Auteur
Alejandro Rodriguez
  • Fonction : Auteur
Jose Andrade Gomes
  • Fonction : Auteur
Pedro Povoa
  • Fonction : Auteur

Résumé

Purpose: Ventilator-associated tracheobronchitis (VAT) has been suggested as an intermediate process between tracheobronchial colonization and ventilator-associated pneumonia (VAP) in patients receiving mechanical ventilation. The aim of this study was to evaluate the ability of C-reactive protein (CRP) and procalcitonin (PCT) to differentiate between VAT and VAP. Methods: Pre-planned analysis of the prospective multinational TAVeM database, performed on 2960 patients receiving mechanical ventilation for >48 h, including 689 patients with VA-LRTI. Patients with the diagnosis of VAT or VAP microbiologically documented and with one measurement of CRP and/or PCT on the day of diagnosis were included. Results: Four hundred and four patients (mean age 63 years, 298 men, ICU mortality 40%) were studied, 207 with VAT and 197 with VAP. On the day of infection diagnosis, the median CRP was elevated in both groups but significantly higher in VAP (18 mg/dL vs. 14 mg/dL, p = .001). Median PCT was also significantly higher in VAP (2.1 ng/dL vs. 0.64 ng/d L, p < .001). Both biomarkers could not help distinguish between VAT and VAP. Conclusion: Although PCT and CRP presented lower values in VAT as compared to VAP, there was a marked overlap of both biomarkers values in both VA-LRTI not allowing adequate discrimination.
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Dates et versions

hal-04318182 , version 1 (01-12-2023)

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Luis Coelho, Ligia Rabello, Jorge Salluh, Ignacio Martin-Loeches, Alejandro Rodriguez, et al.. C-reactive protein and procalcitonin profile in ventilator-associated lower respiratory infections.. Journal of Critical Care, 2018, Journal of Critical Care, 48, pp.385-389. ⟨10.1016/j.jcrc.2018.09.036⟩. ⟨hal-04318182⟩

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